| Date | Time | LevelName | HomeTeams | AwayTeams | SiteName |
| 08/17/2022 | 6:30 PM | 1A | Bowman High School | Pelion High School | Bethune-Bowman Middle/High School |
| 08/18/2022 | 7:00 PM | 2A | Barnwell High School | Williston-elko High School | Barnwell High School |
| 08/18/2022 | 7:00 PM | 3A | Chester High School | Lancaster High School | Chester High School |
| 08/18/2022 | 7:30 PM | 1A | Great Falls High School | Heathwood Hall | Great Falls High School |
| 08/18/2022 | 7:30 PM | 1A | Lake View High School | Marion High School | Lake View High School |
| 08/19/2022 | 7:00 PM | 3A | Aynor High School | Wilson High School | Aynor High School |
| 08/19/2022 | 7:00 PM | 3A | Beaufort High School | Cane Bay High | Beaufort High School |
| 08/19/2022 | 7:30 PM | 4A | Airport High School | Swansea High School | Airport High School |
| 08/19/2022 | 7:30 PM | 2A | Andrews High School | Philip Simmons High School | Andrews High School |
| 08/19/2022 | 7:30 PM | 1A | Bamberg-Ehrhardt High School | Edisto High School | Bamberg-Ehrhardt High School |
| 08/19/2022 | 7:30 PM | 2A | Bishop England High School | Porter-gaud School | Bishop England High School |
| 08/19/2022 | 7:30 PM | 2A | Blacksburg High School | Buford High School | Blacksburg High School |
| 08/19/2022 | 7:30 PM | 3A | Blue Ridge High School | Chesnee High School | Blue Ridge High School |
| 08/19/2022 | 7:30 PM | 4A | Bluffton High School | TBA | Bluffton High School |
| 08/19/2022 | 7:30 PM | 1A | Branchville Middle High School | TBA | Branchville High School |
| 08/19/2022 | 7:30 PM | 1A | Burke High School | R B Stall High School | Burke High School |
| 08/19/2022 | 7:30 PM | 1A | Calhoun County High School | Cross High School | Calhoun County High School |
| 08/19/2022 | 7:30 PM | 1A | Calhoun Falls High School | TBA | Calhoun Falls High School |
| 08/19/2022 | 7:30 PM | 3A | Camden High School | Myrtle Beach High School | Camden City Arena |
| 08/19/2022 | 7:30 PM | 5A | Carolina Forest HS | West Brunswick High School | Carolina Forest High School |
| 08/19/2022 | 7:30 PM | 3A | Carolina High School | Liberty High School | Carolina High School |
| 08/19/2022 | 7:30 PM | 3A | Chapman High School | Woodruff High School | Chapman High School |
| 08/19/2022 | 7:30 PM | 3A | Clinton High School | Batesburg-leesville High School | Clinton Middle School |
| 08/19/2022 | 7:30 PM | 2A | Columbia High School | C A Johnson High School | Bolden Stadium |
| 08/19/2022 | 7:30 PM | 5A | Conway High School | Hartsville High School | Conway High School |
| 08/19/2022 | 7:30 PM | 3A | Crescent High School | Pickens High School | Crescent High School |
| 08/19/2022 | 7:30 PM | 3A | D W Daniel High School | Greer Senior High School | D W Daniel High School |
| 08/19/2022 | 7:30 PM | 5A | Dorman High School | Greenville Sr High School | Dorman High School |
| 08/19/2022 | 7:30 PM | 1A | East Clarendon High School | Lewisville High School | East Clarendon High School |
| 08/19/2022 | 7:30 PM | 1A | Estill High School | Ridgeland | Estill High School |
| 08/19/2022 | 7:30 PM | 3A | Fairfield Central High School | Carvers Bay High School | Fairfield Central High School |
| 08/19/2022 | 7:30 PM | 5A | Fort Mill High School | Catawba Ridge High School | Fort Mill High School |
| 08/19/2022 | 7:30 PM | 3A | Fountain Inn High School | West Oak High School | Fountain Inn High School |
| 08/19/2022 | 7:30 PM | 3A | Gettys D Broome High School | Powdersville High School | Gettys D. Broome High School |
| 08/19/2022 | 7:30 PM | 5A | Goose Creek High School | South Florence High School | Goose Creek High School |
| 08/19/2022 | 7:30 PM | 3A | Hanahan High School | Georgetown High School | Hanahan High School |
| 08/19/2022 | 7:30 PM | 1A | Hemingway High School | Lamar High School | Hemingway High School |
| 08/19/2022 | 7:30 PM | 5A | Hillcrest High School | Laurens District 55 High School | Hillcrest High School |
| 08/19/2022 | 7:30 PM | 4A | Hilton Head High School | Battery Creek High School | Hilton Head High School |
| 08/19/2022 | 7:30 PM | 5A | Irmo High School | Chapin High School | Irmo High School |
| 08/19/2022 | 7:30 PM | 5A | J L Mann High School | Eastside High School | JL Mann High School |
| 08/19/2022 | 7:30 PM | 5A | James Byrnes High School | Brookland-Cayce High School | James F. Byrnes High School |
| 08/19/2022 | 7:30 PM | 5A | James Island Charter High School | St. John’s High School | James Island Charter High School |
| 08/19/2022 | 7:30 PM | 1A | Johnsonville High School | North Central High School | Johnsonville High School |
| 08/19/2022 | 7:30 PM | 2A | Kingstree Senior High School | Manning High School | Kingstree Senior High School |
| 08/19/2022 | 7:30 PM | 3A | Lake City High School | TBA | Lake City High School |
| 08/19/2022 | 7:30 PM | 2A | Lake Marion High School & Technology Center | Lucy Beckham High School | Lake Marion High School & Technology Center |
| 08/19/2022 | 7:30 PM | 2A | Lee Central High | Chesterfield High School | Lee Central High School |
| 08/19/2022 | 7:30 PM | 3A | Loris High School | Green Sea Floyds High School | Loris High School |
| 08/19/2022 | 7:30 PM | 4A | Lugoff-elgin High School | River Bluff High School | Lugoff-Elgin High School |
| 08/19/2022 | 7:30 PM | 1A | Mc Bee High School | Hannah-pamplico High School | Mc Bee High School |
| 08/19/2022 | 7:30 PM | 1A | Mc Cormick High School | Abbeville High School | McCormick High School |
| 08/19/2022 | 7:30 PM | 4A | Midland Valley High School | Grovetown High School | Midland Valley HS |
| 08/19/2022 | 7:30 PM | 2A | Mullins High School | Latta High School | Mullins High School |
| 08/19/2022 | 7:30 PM | 5A | Nation Ford High School | Indian Land High School | Nation Ford HS |
| 08/19/2022 | 7:30 PM | 2A | Ninety Six High School | Emerald High School | Ninety Six High School |
| 08/19/2022 | 7:30 PM | 3A | North Charleston High School | Military Magnet Academy | Charleston D 4 Stadium |
| 08/19/2022 | 7:30 PM | 4A | North Myrtle Beach High School | Socastee High School | North Myrtle Beach High School |
| 08/19/2022 | 7:30 PM | 4A | Northwestern High School | Rock Hill High School | Northwestern High School |
| 08/19/2022 | 7:30 PM | 2A | Oceanside Collegiate Academy | Gray Collegiate Academy | The Citadel |
| 08/19/2022 | 7:30 PM | 3A | Palmetto High School | Woodmont High School | Palmetto High School |
| 08/19/2022 | 7:30 PM | 3A | Pendleton High School | Dixie High School | Pendleton High School |
| 08/19/2022 | 7:30 PM | 4A | Richland Northeast High School | Crestwood High School | Richland Northeast High School |
| 08/19/2022 | 7:30 PM | 4A | Ridge View High School | Blythewood High School | Ridge View High School |
| 08/19/2022 | 7:30 PM | 4A | Riverside High School | Travelers Rest High School | Riverside High School |
| 08/19/2022 | 7:30 PM | 2A | Saluda High School | Mid-carolina High School | Saluda High School |
| 08/19/2022 | 7:30 PM | 2A | Silver Bluff High School | South Aiken High School | Silver Bluff High School |
| 08/19/2022 | 7:30 PM | 1A | Southside Christian School | TBA | Southside Christian School |
| 08/19/2022 | 7:30 PM | 5A | Spring Valley High School | Westwood High School | Spring Valley High School |
| 08/19/2022 | 7:30 PM | 2A | St. Joseph High School | Fox Creek High School | St. Joseph High School |
| 08/19/2022 | 7:30 PM | 5A | Sumter High School | Lakewood High School | Lakewood High School |
| 08/19/2022 | 7:30 PM | 5A | T L Hanna High School | Boiling Springs High School | T L Hanna High School |
| 08/19/2022 | 7:30 PM | 2A | Timberland High School | Berkeley High School | Timberland High School |
| 08/19/2022 | 7:30 PM | 3A | W J Keenan High School | Dreher High School | Keenan High School |
| 08/19/2022 | 7:30 PM | 3A | Waccamaw High School | St. James High School | Waccamaw High School |
| 08/19/2022 | 7:30 PM | 4A | Wade Hampton High School (Greenville) | Seneca | Wade Hampton High School (G) |
| 08/19/2022 | 7:30 PM | 2A | Wade Hampton High School (Hampton) | Colleton County | Wade Hampton High School (H) |
| 08/19/2022 | 7:30 PM | 1A | Wagener-salley High School | Allendale-fairfax High School | Wagener-Salley High School |
| 08/19/2022 | 7:30 PM | 5A | West Ashley High School | Lower Richland High School | West Ashley High School |
| 08/19/2022 | 7:30 PM | 4A | West Florence High School | Lexington High School | West Florence High School |
| 08/19/2022 | 7:30 PM | 5A | White Knoll High School | Orangeburg-wilkinson High School | White Knoll High School |
| 08/19/2022 | 7:30 PM | 1A | Whitmire High School | Ware Shoals High School | Whitmire High School |
| 08/19/2022 | 8:00 PM | 4A | A C Flora High School | Greenwood High School | A C Flora High School |
| 08/19/2022 | 8:00 PM | 1A | Hunter-kinard-tyler Middle High School | Scott’s Branch | Hunter-Kinard-Tyler High School |
| 08/19/2022 | 8:00 PM | 2A | Newberry High School | Union High School | Newberry High School |
| 08/20/2022 | 4:30 PM | 4A | TBA | TBA | Dist. 3 Sta. – Rock Hill |
| 08/20/2022 | 7:30 PM | 4A | South Pointe High School | Gaffney High School | Dist. 3 Sta. – Rock Hill |
| 08/25/2022 | 7:30 PM | 1A | Blackville-hilda High School | Barnwell High School | Blackville-Hilda High School |
| 08/26/2022 | 7:00 PM | 1A | Ridge Spring-Monetta High School | Saluda High School | Ridge Spring-Monetta High School |
| 08/26/2022 | 7:30 PM | 2A | Abbeville High School | Powdersville High School | Abbeville High School |
| 08/26/2022 | 7:30 PM | 2A | Andrew Jackson High School | Fairfield Central High School | Andrew Jackson High School |
| 08/26/2022 | 7:30 PM | 2A | Andrews High School | Georgetown High School | Andrews High School |
| 08/26/2022 | 7:30 PM | 3A | Aynor High School | Kingstree Senior High School | Aynor High School |
| 08/26/2022 | 7:30 PM | 1A | Bamberg-Ehrhardt High School | Denmark-Olar High School | Bamberg-Ehrhardt High School |
| 08/26/2022 | 7:30 PM | 1A | Baptist Hill High School | St. John’s High School | Baptist Hill High School |
| 08/26/2022 | 7:30 PM | 2A | Batesburg-leesville High School | TBA | Batesburg-Leesville High School |
| 08/26/2022 | 7:30 PM | 4A | Berea High School | Landrum High School | Berea High School |
| 08/26/2022 | 7:30 PM | 5A | Blythewood High School | Richland Northeast High School | Blythewood High School |
| 08/26/2022 | 7:30 PM | 5A | Boiling Springs High School | Mauldin High School | Boiling Springs High School |
| 08/26/2022 | 7:30 PM | 3A | Brookland-Cayce High School | Airport High School | Brookland-Cayce High School Arena |
| 08/26/2022 | 7:30 PM | 2A | Buford High School | Mc Bee High School | Buford High School |
| 08/26/2022 | 7:30 PM | 1A | C A Johnson High School | Estill High School | Bolden Stadium |
| 08/26/2022 | 7:30 PM | 1A | Calhoun County High School | Lake Marion High School & Technology Center | Calhoun County High School |
| 08/26/2022 | 7:30 PM | 1A | Calhoun Falls High School | TBA | Calhoun Falls High School |
| 08/26/2022 | 7:30 PM | 5A | Cane Bay High | Ashley Ridge High | Cane Bay High School |
| 08/26/2022 | 7:30 PM | 1A | Carvers Bay High School | Waccamaw High School | Carvers Bay High School |
| 08/26/2022 | 7:30 PM | 4A | Catawba Ridge High School | Charlotte Latin School | Catawba Ridge High School |
| 08/26/2022 | 7:30 PM | 2A | Central High School | TBA | Central High School |
| 08/26/2022 | 7:30 PM | 2A | Chesnee High School | Gettys D Broome High School | Chesnee High School |
| 08/26/2022 | 7:30 PM | 3A | Clinton High School | Laurens District 55 High School | Clinton Middle School |
| 08/26/2022 | 7:30 PM | 5A | Clover High School | Northwestern High School | Clover High School |
| 08/26/2022 | 7:30 PM | 3A | Crestwood High School | Gray Collegiate Academy | Sumter Dist 2 Sta: Crestw |
| 08/26/2022 | 7:30 PM | 1A | Cross High School | Hemingway High School | Cross High School |
| 08/26/2022 | 7:30 PM | 3A | Dillon High School | Lamar High School | Dillon High School |
| 08/26/2022 | 7:30 PM | 1A | Dixie High School | Crescent High School | Dixie High School |
| 08/26/2022 | 7:30 PM | 5A | Easley High School | D W Daniel High School | Easley High School |
| 08/26/2022 | 7:30 PM | 1A | East Clarendon High School | Latta High School | East Clarendon High School |
| 08/26/2022 | 7:30 PM | 4A | Eastside High School | Pendleton High School | Eastside High School |
| 08/26/2022 | 7:30 PM | 2A | Eau Claire High School | Hunter-kinard-tyler Middle High School | Keenan High School |
| 08/26/2022 | 7:30 PM | 5A | Fort Dorchester High School | Beaufort High School | Fort Dorchester High School |
| 08/26/2022 | 7:30 PM | 5A | Fort Mill High School | Chester High School | Fort Mill High School |
| 08/26/2022 | 7:30 PM | 3A | Fountain Inn High School | Woodruff High School | Fountain Inn High School |
| 08/26/2022 | 7:30 PM | 4A | Greenville Sr High School | T L Hanna High School | G’ville’s – Sirrine Sta |
| 08/26/2022 | 7:30 PM | 4A | Greenwood High School | TBA | Greenwood High School |
| 08/26/2022 | 7:30 PM | 5A | Greer Senior High School | Hillcrest High School | Greer HS Stadium |
| 08/26/2022 | 7:30 PM | 3A | Hanahan High School | Berkeley High School | Hanahan High School |
| 08/26/2022 | 7:30 PM | 4A | Hartsville High School | Darlington High School | Hartsville High School |
| 08/26/2022 | 7:30 PM | 4A | Indian Land High School | Timberland High School | Indian Land High School |
| 08/26/2022 | 7:30 PM | 5A | James Byrnes High School | Chapman High School | James F. Byrnes High School |
| 08/26/2022 | 7:30 PM | 1A | Johnsonville High School | Green Sea Floyds High School | Johnsonville High School |
| 08/26/2022 | 7:30 PM | 3A | Lake City High School | West Florence High School | Lake City High School |
| 08/26/2022 | 7:30 PM | 3A | Lakewood High School | Fox Creek High School | Lakewood High School |
| 08/26/2022 | 7:30 PM | 4A | Lancaster High School | Irmo High School | Lancaster High School |
| 08/26/2022 | 7:30 PM | 2A | Lee Central High | Great Falls High School | Lee Central High School |
| 08/26/2022 | 7:30 PM | 1A | Lewisville High School | Wagener-salley High School | Lewisville High School |
| 08/26/2022 | 7:30 PM | 2A | Liberty High School | Blue Ridge High School | Liberty HS |
| 08/26/2022 | 7:30 PM | 4A | Lugoff-elgin High School | Camden High School | Lugoff-Elgin High School |
| 08/26/2022 | 7:30 PM | 2A | Marion High School | Wilson High School | Marion High School |
| 08/26/2022 | 7:30 PM | 3A | Marlboro County High School | Cheraw Senior High School | Marlboro County High School |
| 08/26/2022 | 7:30 PM | 1A | Mc Cormick High School | Lincoln County High School | McCormick High School |
| 08/26/2022 | 7:30 PM | 2A | Mid-carolina High School | Chapin High School | Mid Carolina High School |
| 08/26/2022 | 7:30 PM | 1A | Military Magnet Academy | Academic Magnet High School | Garrett Acad. – Ayoub Sta |
| 08/26/2022 | 7:30 PM | 2A | Mullins High School | Lake View High School | Mullins High School |
| 08/26/2022 | 7:30 PM | 4A | North Augusta High School | Dorman High School | North Augusta High School |
| 08/26/2022 | 7:30 PM | 2A | North Central High School | Hannah-pamplico High School | North Central High School |
| 08/26/2022 | 7:30 PM | 4A | North Myrtle Beach High School | Loris High School | North Myrtle Beach High School |
| 08/26/2022 | 7:30 PM | 3A | Orangeburg-wilkinson High School | W J Keenan High School | Orangeburg-Wilkinson High School |
| 08/26/2022 | 7:30 PM | 3A | Palmetto High School | Seneca | Palmetto High School |
| 08/26/2022 | 7:30 PM | 2A | Pelion High School | Columbia | Pelion High School |
| 08/26/2022 | 7:30 PM | 3A | Philip Simmons High School | St. James High School | Philip Simmons High School |
| 08/26/2022 | 7:30 PM | 4A | Pickens High School | TBA | Pickens High School |
| 08/26/2022 | 7:30 PM | 5A | R B Stall High School | James Island Charter High School | Charleston District 4 Stadium |
| 08/26/2022 | 7:30 PM | 4A | Ridge View High School | Sumter High School | Ridge View High School |
| 08/26/2022 | 7:30 PM | 3A | Ridgeland | Battery Creek High School | Ridgeland-Hardeeville High School |
| 08/26/2022 | 7:30 PM | 5A | River Bluff High School | Swansea High School | River Bluff High School |
| 08/26/2022 | 7:30 PM | 4A | Riverside High School | J L Mann High School | Riverside High School |
| 08/26/2022 | 7:30 PM | 5A | Rock Hill High School | South Pointe High School | Rock Hill High School |
| 08/26/2022 | 7:30 PM | 1A | Scott’s Branch | Manning High School | Scott’s Branch HS |
| 08/26/2022 | 7:30 PM | 5A | Socastee High School | Silver Bluff High School | Socastee High School |
| 08/26/2022 | 7:30 PM | 4A | South Aiken High School | Lexington High School | South Aiken High School |
| 08/26/2022 | 7:30 PM | 4A | South Florence | Oceanside Collegiate Academy | South Florence High School |
| 08/26/2022 | 7:30 PM | 3A | Southside High School | Christ Church Episcopal School | Southside High School Court – MAIN GYM |
| 08/26/2022 | 7:30 PM | 5A | Spartanburg High School | Dutch Fork High School | Spartanburg High School |
| 08/26/2022 | 7:30 PM | 2A | St. Joseph High School | Blacksburg High School | St. Joseph High School |
| 08/26/2022 | 7:30 PM | 3A | Strom Thurmond High School | Midland Valley High School | Strom Thurmond H |
| 08/26/2022 | 7:30 PM | 5A | Summerville High School | Carolina Forest HS | Summerville-Memorial Sta. |
| 08/26/2022 | 7:30 PM | 3A | Travelers Rest High School | Wade Hampton High School (Greenville) | Travelers Rest High School |
| 08/26/2022 | 7:30 PM | 3A | Union High School | Gaffney High School | Union High School |
| 08/26/2022 | 7:30 PM | 2A | Wade Hampton High School (Hampton) | Allendale-fairfax High School | Wade Hampton High School (H) |
| 08/26/2022 | 7:30 PM | 3A | Walhalla Senior High School | Woodmont High School | Walhalla High School |
| 08/26/2022 | 7:30 PM | 5A | Wando High School | Lucy Beckham High School | Wando High School Stadium |
| 08/26/2022 | 7:30 PM | 1A | Ware Shoals High School | Ninety Six High School | Ware Shoals High School |
| 08/26/2022 | 7:30 PM | 5A | West Ashley High School | May River High School – Squad 1 | West Ashley High School |
| 08/26/2022 | 7:30 PM | 3A | West Oak High School | TBA | West Oak High School |
| 08/26/2022 | 7:30 PM | 4A | Westside High School | Belton-honea Path High School | Westside High School |
| 08/26/2022 | 7:30 PM | 4A | Westwood High School | Lower Richland High School | Westwood High School |
| 08/26/2022 | 7:30 PM | 1A | Whale Branch Early College High School | North Charleston High School | Whale Branch Early College High School |
| 08/26/2022 | 7:30 PM | 5A | White Knoll High School | Spring Valley High School | White Knoll High School |
| 08/26/2022 | 7:30 PM | 1A | Williston-elko High School | Edisto High School | Williston-Elko High School |
| 08/26/2022 | 7:30 PM | 2A | Woodland High School | Bowman High School | Woodland High School |
| 08/26/2022 | 7:30 PM | 4A | York Comprehensive High School | Nation Ford High School | York High School |
| 08/26/2022 | 8:00 PM | 3A | Dreher High School | A C Flora High School | Memorial Stadium-Columbia |
| 08/27/2022 | 7:00 PM | 4A | Myrtle Beach High School | Conway High School | Myrtle Beach High School |
| 09/01/2022 | 7:30 PM | 2A | Fox Creek High School | Mc Cormick High School | North Augusta Rec Center |
| 09/01/2022 | 7:30 PM | 3A | North Charleston High School | Baptist Hill High School | Charleston D 4 Stadium |
| 09/02/2022 | 7:00 PM | 1A | Ridge Spring-Monetta High School | Batesburg-leesville High School | Ridge Spring-Monetta High School |
| 09/02/2022 | 7:30 PM | 2A | Abbeville High School | Southside Christian School | Abbeville High School |
| 09/02/2022 | 7:30 PM | 2A | Academic Magnet High School | Burke High School | Ravenel Field |
| 09/02/2022 | 7:30 PM | 4A | Aiken High School | Strom Thurmond High School | Aiken High School |
| 09/02/2022 | 7:30 PM | 4A | Airport High School | TBA | Airport High School |
| 09/02/2022 | 7:30 PM | 1A | Allendale-fairfax High School | Blackville-hilda High School | Allendale Fairfax High School |
| 09/02/2022 | 7:30 PM | 2A | Andrew Jackson High School | Crestwood High School | Andrew Jackson High School |
| 09/02/2022 | 7:30 PM | 5A | Ashley Ridge High | Conway High School | Ashley Ridge High School |
| 09/02/2022 | 7:30 PM | 2A | Barnwell High School | Bamberg-Ehrhardt High School | Barnwell High School |
| 09/02/2022 | 7:30 PM | 3A | Beaufort High School | Hilton Head High School | Beaufort High School |
| 09/02/2022 | 7:30 PM | 3A | Belton-honea Path High School | Laurens District 55 High School | Belton-Honea Path High School |
| 09/02/2022 | 7:30 PM | 5A | Berkeley High School | Summerville High School | Berkeley High School |
| 09/02/2022 | 7:30 PM | 2A | Blacksburg High School | TBA | Blacksburg High School |
| 09/02/2022 | 7:30 PM | 5A | Blythewood High School | Westwood High School | Blythewood High School |
| 09/02/2022 | 7:30 PM | 2A | Buford High School | Lee Central High | Buford High School |
| 09/02/2022 | 7:30 PM | 1A | Calhoun County High School | Battery Creek High School | Calhoun County High School |
| 09/02/2022 | 7:30 PM | 3A | Camden High School | Hartsville High School | Camden City Arena |
| 09/02/2022 | 7:30 PM | 5A | Cane Bay High | West Ashley High School | Cane Bay High School |
| 09/02/2022 | 7:30 PM | 3A | Carolina High School | Berea High School | Carolina High School |
| 09/02/2022 | 7:30 PM | 1A | Carvers Bay High School | Andrews High School | Carvers Bay High School |
| 09/02/2022 | 7:30 PM | 4A | Catawba Ridge High School | Nation Ford High School | Catawba Ridge High School |
| 09/02/2022 | 7:30 PM | 5A | Chapin High School | Spring Valley High School | Chapin High School |
| 09/02/2022 | 7:30 PM | 3A | Chapman High School | Boiling Springs High School | Chapman High School |
| 09/02/2022 | 7:30 PM | 2A | Cheraw Senior High School | Hannah-pamplico High School | Cheraw Senior High School |
| 09/02/2022 | 7:30 PM | 2A | Chesnee High School | Walhalla Senior High School | Chesnee High School |
| 09/02/2022 | 7:30 PM | 2A | Christ Church Episcopal School | TBA | Christ Church Episcopal School |
| 09/02/2022 | 7:30 PM | 3A | Crescent High School | Fountain Inn High School | Crescent High School |
| 09/02/2022 | 7:30 PM | 3A | Darlington High School | Lugoff-elgin High School | Darlington High School |
| 09/02/2022 | 7:30 PM | 1A | Denmark-Olar High School | St. John’s High School | Denmark-Olar High School |
| 09/02/2022 | 7:30 PM | 1A | Dixie High School | Greenwood Christian School | Dixie High School |
| 09/02/2022 | 7:30 PM | 5A | Dorman High School | Greenwood High School | Dorman High School |
| 09/02/2022 | 7:30 PM | 4A | Eastside High School | Liberty High School | Eastside High School |
| 09/02/2022 | 7:30 PM | 2A | Edisto High School | Columbia | Edisto High School |
| 09/02/2022 | 7:30 PM | 3A | Emerald High School | Ware Shoals High School | Emerald High School |
| 09/02/2022 | 7:30 PM | 1A | Estill High School | TBA | Estill High School |
| 09/02/2022 | 7:30 PM | 3A | Fairfield Central High School | Chester High School | Fairfield Central High School |
| 09/02/2022 | 7:30 PM | 5A | Gaffney High School | TBA | Gaffney High School |
| 09/02/2022 | 7:30 PM | 3A | Gettys D Broome High School | Spartanburg High School | Gettys D. Broome High School |
| 09/02/2022 | 7:30 PM | 3A | Gilbert High School | South Aiken High School | Gilbert High School |
| 09/02/2022 | 7:30 PM | 1A | Green Sea Floyds High School | Mullins High School | Green Sea Floyds High School |
| 09/02/2022 | 7:30 PM | 4A | Greenville Sr High School | James Byrnes High School | G’ville’s – Sirrine Sta |
| 09/02/2022 | 7:30 PM | 4A | Greer Senior High School | Blue Ridge High School | Greer HS Stadium |
| 09/02/2022 | 7:30 PM | 5A | Hillcrest High School | Clover High School | Hillcrest High School |
| 09/02/2022 | 7:30 PM | 5A | James Island Charter High School | First Baptist Church School | James Island Charter High School |
| 09/02/2022 | 7:30 PM | 2A | Kingstree Senior High School | Lake City High School | Kingstree Senior High School |
| 09/02/2022 | 7:30 PM | 1A | Lake View High School | Hemingway High School | Lake View High School |
| 09/02/2022 | 7:30 PM | 3A | Lakewood High School | Dreher High School | Lakewood High School |
| 09/02/2022 | 7:30 PM | 1A | Lamar High School | Legion Collegiate Academy | Lamar High School |
| 09/02/2022 | 7:30 PM | 4A | Lancaster High School | Rock Hill High School | Lancaster High School |
| 09/02/2022 | 7:30 PM | 2A | Landrum High School | St. Joseph High School | Landrum High School |
| 09/02/2022 | 7:30 PM | 1A | Latta High School | Mc Bee High School | Buddy Johnson Park – Latta |
| 09/02/2022 | 7:30 PM | 1A | Lewisville High School | Chesterfield High School | Lewisville High School |
| 09/02/2022 | 7:30 PM | 5A | Lexington High School | Stratford High School | Lexington High School |
| 09/02/2022 | 7:30 PM | 3A | Lower Richland High School | Ridge View High School | Lower Richland High School |
| 09/02/2022 | 7:30 PM | 4A | Lucy Beckham High School | Bishop England High School | Wando High School Stadium |
| 09/02/2022 | 7:30 PM | 3A | Manning High School | East Clarendon High School | Manning High School |
| 09/02/2022 | 7:30 PM | 2A | Marion High School | Central High School | Marion High School |
| 09/02/2022 | 7:30 PM | 5A | Mauldin High School | Powdersville High School | Mauldin High School |
| 09/02/2022 | 7:30 PM | 4A | Midland Valley High School | Silver Bluff High School | Midland Valley HS |
| 09/02/2022 | 7:30 PM | 4A | Myrtle Beach High School | St. James High School | Myrtle Beach High School |
| 09/02/2022 | 7:30 PM | 2A | Ninety Six High School | Saluda High School | Ninety Six High School |
| 09/02/2022 | 7:30 PM | 4A | North Augusta High School | Lakeside-Evans | North Augusta High School |
| 09/02/2022 | 7:30 PM | 2A | North Central High School | C A Johnson High School | North Central High School |
| 09/02/2022 | 7:30 PM | 4A | Northwestern High School | Brookland-Cayce High School | Northwestern High School |
| 09/02/2022 | 7:30 PM | 2A | Oceanside Collegiate Academy | Carolina Forest HS | The Citadel |
| 09/02/2022 | 7:30 PM | 3A | Orangeburg-wilkinson High School | South Florence High School | Orangeburg-Wilkinson High School |
| 09/02/2022 | 7:30 PM | 3A | Palmetto High School | Travelers Rest High School | Palmetto High School |
| 09/02/2022 | 7:30 PM | 2A | Pelion High School | Eau Claire High School | Pelion High School |
| 09/02/2022 | 7:30 PM | 3A | Philip Simmons High School | Georgetown High School | Philip Simmons High School |
| 09/02/2022 | 7:30 PM | 4A | Pickens High School | Southside High School | Pickens High School |
| 09/02/2022 | 7:30 PM | 5A | R B Stall High School | Wando High School | Charleston Distr. 4 Stadium |
| 09/02/2022 | 7:30 PM | 5A | River Bluff High School | Irmo High School | River Bluff High School |
| 09/02/2022 | 7:30 PM | 3A | Seneca | Wren High School | Seneca High |
| 09/02/2022 | 7:30 PM | 4A | South Pointe High School | Mallard Creek High School | South Pointe High School |
| 09/02/2022 | 7:30 PM | 5A | Sumter High School | Goose Creek High School | Sumter-Memorial Sta |
| 09/02/2022 | 7:30 PM | 5A | T L Hanna High School | Westside High School | T L Hanna High School |
| 09/02/2022 | 7:30 PM | 2A | Timberland High School | Cross High School | Timberland High School |
| 09/02/2022 | 7:30 PM | 3A | Union High School | York Comprehensive High School | Union High School |
| 09/02/2022 | 7:30 PM | 3A | W J Keenan High School | Richland Northeast High School | Keenan High School |
| 09/02/2022 | 7:30 PM | 3A | Waccamaw High School | TBA | Waccamaw High School |
| 09/02/2022 | 7:30 PM | 4A | Wade Hampton High School (Greenville) | Easley High School | Wade Hampton High School (G) |
| 09/02/2022 | 7:30 PM | 1A | Wagener-salley High School | Lake Marion High School & Technology Center | Wagener-Salley High School |
| 09/02/2022 | 7:30 PM | 4A | West Florence High School | Socastee High School | West Florence High School |
| 09/02/2022 | 7:30 PM | 3A | West Oak High School | TBA | West Oak High School |
| 09/02/2022 | 7:30 PM | 1A | Whale Branch Early College High School | Ridgeland | Whale Branch Early College High School |
| 09/02/2022 | 7:30 PM | 5A | White Knoll High School | Colleton County | White Knoll High School |
| 09/02/2022 | 7:30 PM | 1A | Whitmire High School | Mid-carolina High School | Whitmire High School |
| 09/02/2022 | 7:30 PM | 4A | Wilson High School | Dillon High School | Wilson High School |
| 09/02/2022 | 7:30 PM | 2A | Woodland High School | Bluffton High School | Woodland High School |
| 09/02/2022 | 7:30 PM | 5A | Woodmont High School | Riverside High School | Woodmont High School |
| 09/02/2022 | 7:30 PM | 3A | Woodruff High School | J L Mann High School | Woodruff High School |
| 09/02/2022 | 8:00 PM | 1A | Hunter-kinard-tyler Middle High School | Bowman High School | Hunter-Kinard-Tyler High School |
| 09/02/2022 | 8:00 PM | 2A | Newberry High School | Clinton High School | Newberry High School |
| 09/08/2022 | 7:00 PM | 5A | J L Mann High School – JV | Easley High School | J. L. Mann HS Sports Complex |
| 09/09/2022 | 7:30 PM | 2A | Academic Magnet High School | Bowman High School | Ravenel Field |
| 09/09/2022 | 7:30 PM | 4A | Aiken High School | Clinton High School | Aiken High School |
| 09/09/2022 | 7:30 PM | 4A | Airport High School | Lugoff-elgin High School | Airport High School |
| 09/09/2022 | 7:30 PM | 3A | Aynor High School | Lakewood High School | Aynor High School |
| 09/09/2022 | 7:30 PM | 1A | Baptist Hill High School | Whale Branch Early College High School | Baptist Hill High School |
| 09/09/2022 | 7:30 PM | 3A | Battery Creek High School | TBA | Battery Creek High School |
| 09/09/2022 | 7:30 PM | 3A | Beaufort High School | Goose Creek High School | Beaufort High School |
| 09/09/2022 | 7:30 PM | 4A | Berea High School | Wade Hampton High School (Greenville) | Berea High School |
| 09/09/2022 | 7:30 PM | 2A | Blacksburg High School | Lewisville High School | Blacksburg High School |
| 09/09/2022 | 7:30 PM | 1A | Blackville-hilda High School | Bamberg-Ehrhardt High School | Blackville-Hilda High School |
| 09/09/2022 | 7:30 PM | 3A | Blue Ridge High School | Eastside High School | Blue Ridge High School |
| 09/09/2022 | 7:30 PM | 5A | Boiling Springs High School | Hillcrest High School | Boiling Springs High School |
| 09/09/2022 | 7:30 PM | 1A | Branchville Middle High School | Williston-elko High School | Branchville High School |
| 09/09/2022 | 7:30 PM | 3A | Brookland-Cayce High School | A C Flora High School | Brookland-Cayce High School Arena |
| 09/09/2022 | 7:30 PM | 1A | Burke High School | Calhoun County High School | Burke High School |
| 09/09/2022 | 7:30 PM | 1A | C A Johnson High School | Wade Hampton High School (Hampton) | Bolden Stadium |
| 09/09/2022 | 7:30 PM | 3A | Camden High School | Gray Collegiate Academy | Camden City Arena |
| 09/09/2022 | 7:30 PM | 3A | Carolina High School | Fountain Inn High School | Carolina High School |
| 09/09/2022 | 7:30 PM | 1A | Carvers Bay High School | Georgetown High School | Carvers Bay High School |
| 09/09/2022 | 7:30 PM | 4A | Catawba Ridge High School | TBA | Catawba Ridge High School |
| 09/09/2022 | 7:30 PM | 2A | Central High School | TBA | Central High School |
| 09/09/2022 | 7:30 PM | 5A | Chapin High School | Newberry High School | Chapin High School |
| 09/09/2022 | 7:30 PM | 2A | Cheraw Senior High School | Darlington High School | Cheraw Senior High School |
| 09/09/2022 | 7:30 PM | 3A | Chester High School | South Pointe High School | Chester High School |
| 09/09/2022 | 7:30 PM | 2A | Chesterfield High School | Lake View High School | Chesterfield High School |
| 09/09/2022 | 7:30 PM | 4A | Colleton County | Ashley Ridge High | Colleton County High School |
| 09/09/2022 | 7:30 PM | 5A | Conway High School | North Myrtle Beach High School | Conway High School |
| 09/09/2022 | 7:30 PM | 3A | Crestwood High School | Sumter High School | Sumter Dist. 2 – Sta |
| 09/09/2022 | 7:30 PM | 1A | Cross High School | Scott’s Branch | Cross High School |
| 09/09/2022 | 7:30 PM | 3A | D W Daniel High School | TBA | D W Daniel High School |
| 09/09/2022 | 7:30 PM | 1A | Denmark-Olar High School | Allendale-fairfax High School | Denmark-Olar High School |
| 09/09/2022 | 7:30 PM | 3A | Dreher High School | West Florence High School | Memorial Stadium-Columbia |
| 09/09/2022 | 7:30 PM | 5A | Easley High School | J L Mann High School | Easley High School |
| 09/09/2022 | 7:30 PM | 2A | Eau Claire High School | Whitmire High School | Keenan High School |
| 09/09/2022 | 7:30 PM | 3A | Emerald High School | Saluda High School | Emerald High School |
| 09/09/2022 | 7:30 PM | 1A | Estill High School | Edisto High School | Estill High School |
| 09/09/2022 | 7:30 PM | 5A | Gaffney High School | Mallard Creek High School | Gaffney High School |
| 09/09/2022 | 7:30 PM | 3A | Gettys D Broome High School | Union High School | Gettys D. Broome High School |
| 09/09/2022 | 7:30 PM | 3A | Gilbert High School | Pelion High School | Gilbert High School |
| 09/09/2022 | 7:30 PM | 1A | Great Falls High School | Columbia High School | Great Falls High School |
| 09/09/2022 | 7:30 PM | 1A | Green Sea Floyds High School | Kingstree Senior High School | Green Sea Floyds High School |
| 09/09/2022 | 7:30 PM | 1A | Hannah-pamplico High School | Andrews High School | Hannah-Pamplico High School |
| 09/09/2022 | 7:30 PM | 4A | Hartsville High School | Dillon High School | Hartsville High School |
| 09/09/2022 | 7:30 PM | 1A | Hemingway High School | Marion High School | Hemingway High School |
| 09/09/2022 | 7:30 PM | 4A | Indian Land High School | Fort Mill High School | Indian Land High School |
| 09/09/2022 | 7:30 PM | 5A | James Byrnes High School | Greer Senior High School | James F. Byrnes High School |
| 09/09/2022 | 7:30 PM | 5A | James Island Charter High School | Bishop England High School | James Island Charter High School |
| 09/09/2022 | 7:30 PM | 3A | Lake City High School | St. James High School | Lake City High School |
| 09/09/2022 | 7:30 PM | 1A | Lamar High School | Andrew Jackson High School | Lamar High School |
| 09/09/2022 | 7:30 PM | 4A | Lancaster High School | Fairfield Central High School | Lancaster High School |
| 09/09/2022 | 7:30 PM | 1A | Latta High School | Lee Central High | Buddy Johnson Park – Latta |
| 09/09/2022 | 7:30 PM | 4A | Laurens District 55 High School | Chapman High School | Laurens District 55 High School |
| 09/09/2022 | 7:30 PM | 5A | Lexington High School | Blythewood High School | Lexington High School |
| 09/09/2022 | 7:30 PM | 2A | Liberty High School | Dixie High School | Liberty HS |
| 09/09/2022 | 7:30 PM | 4A | Lucy Beckham High School | Hanahan High School | Wando High School Stadium |
| 09/09/2022 | 7:30 PM | 3A | Manning High School | Lake Marion High School & Technology Center | Manning High School |
| 09/09/2022 | 7:30 PM | 3A | Marlboro County High School | Oceanside Collegiate Academy | Marlboro County High School |
| 09/09/2022 | 7:30 PM | 5A | Mauldin High School | Greenville Sr High School | Mauldin High School |
| 09/09/2022 | 7:30 PM | 1A | Mc Bee High School | East Clarendon High School | Mc Bee High School |
| 09/09/2022 | 7:30 PM | 2A | Mid-carolina High School | Ninety Six High School | Mid Carolina High School |
| 09/09/2022 | 7:30 PM | 2A | Mullins High School | TBA | Mullins High School |
| 09/09/2022 | 7:30 PM | 5A | Nation Ford High School | Northwestern High School | Nation Ford HS |
| 09/09/2022 | 7:30 PM | 4A | North Augusta High School | Greenwood High School | North Augusta High School |
| 09/09/2022 | 7:30 PM | 2A | North Central High School | W J Keenan High School | North Central High School |
| 09/09/2022 | 7:30 PM | 3A | Orangeburg-wilkinson High School | Barnwell High School | Orangeburg-Wilkinson High School |
| 09/09/2022 | 7:30 PM | 3A | Philip Simmons High School | Timberland High School | Philip Simmons High School |
| 09/09/2022 | 7:30 PM | 3A | Powdersville High School | Pendleton High School | Powdersville High School |
| 09/09/2022 | 7:30 PM | 5A | R B Stall High School | North Charleston High School | Charleston District 4 Stadium |
| 09/09/2022 | 7:30 PM | 4A | Ridgeland | May River High School – Squad 1 | Ridgeland-Hardeeville High School |
| 09/09/2022 | 7:30 PM | 4A | Riverside High School | Christ Church Episcopal School | Riverside High School |
| 09/09/2022 | 7:30 PM | 5A | Rock Hill High School | Lower Richland High School | Rock Hill High School |
| 09/09/2022 | 7:30 PM | 3A | Seneca | St. Joseph High School | Seneca High |
| 09/09/2022 | 7:30 PM | 5A | Socastee High School | Myrtle Beach High School | Socastee High School |
| 09/09/2022 | 7:30 PM | 4A | South Aiken High School | River Bluff High School | South Aiken High School |
| 09/09/2022 | 7:30 PM | 4A | South Florence | Carolina Forest HS | South Florence High School |
| 09/09/2022 | 7:30 PM | 5A | Spring Valley High School | Ridge View High School | Spring Valley High School |
| 09/09/2022 | 7:30 PM | 1A | St. John’s High School | Woodland High School | St. John’s High School |
| 09/09/2022 | 7:30 PM | 5A | Stratford High School | Dutch Fork High School | Stratford High School |
| 09/09/2022 | 7:30 PM | 5A | Summerville High School | Wando High School | Summerville-Memorial Sta. |
| 09/09/2022 | 7:30 PM | 3A | Swansea High School | Wagener-salley High School | Swansea High School |
| 09/09/2022 | 7:30 PM | 3A | Waccamaw High School | Johnsonville High School | Waccamaw High School |
| 09/09/2022 | 7:30 PM | 3A | Walhalla Senior High School | Southside High School | Walhalla High School |
| 09/09/2022 | 7:30 PM | 5A | West Ashley High School | Berkeley High School | West Ashley High School |
| 09/09/2022 | 7:30 PM | 3A | West Oak High School | Ware Shoals High School | West Oak High School |
| 09/09/2022 | 7:30 PM | 4A | Westside High School | Abbeville High School | Westside High School |
| 09/09/2022 | 7:30 PM | 4A | Westwood High School | White Knoll High School | Westwood High School |
| 09/09/2022 | 7:30 PM | 4A | Wilson High School | Hilton Head High School | Wilson High School |
| 09/09/2022 | 7:30 PM | 5A | Woodmont High School | Travelers Rest High School | Woodmont High School |
| 09/09/2022 | 7:30 PM | 3A | Woodruff High School | Belton-honea Path High School | Woodruff High School |
| 09/09/2022 | 7:30 PM | 3A | Wren High School | T L Hanna High School | Wren High School |
| 09/09/2022 | 7:30 PM | 4A | York Comprehensive High School | Clover High School | York High School |
| 09/09/2022 | 8:00 PM | 1A | Hunter-kinard-tyler Middle High School | Military Magnet Academy | Hunter-Kinard-Tyler High School |
| 09/10/2022 | 7:30 PM | 5A | Fort Dorchester High School | TBA | Fort Dorchester High School |
| 09/16/2022 | 7:00 PM | 2A | Lee Central High | TBA | Lee Central High School |
| 09/16/2022 | 7:00 PM | 1A | Ridge Spring-Monetta High School | Lewisville High School | Ridge Spring-Monetta High School |
| 09/16/2022 | 7:30 PM | 4A | A C Flora High School | Camden High School | A C Flora High School |
| 09/16/2022 | 7:30 PM | 1A | Allendale-fairfax High School | Baptist Hill High School | Allendale Fairfax High School |
| 09/16/2022 | 7:30 PM | 2A | Andrew Jackson High School | Lakewood High School | Andrew Jackson High School |
| 09/16/2022 | 7:30 PM | 5A | Ashley Ridge High | St. James High School | Ashley Ridge High School |
| 09/16/2022 | 7:30 PM | 2A | Barnwell High School | Aiken High School | Barnwell High School |
| 09/16/2022 | 7:30 PM | 2A | Batesburg-leesville High School | Newberry High School | Batesburg-Leesville High School |
| 09/16/2022 | 7:30 PM | 3A | Belton-honea Path High School | Emerald High School | Belton-Honea Path High School |
| 09/16/2022 | 7:30 PM | 4A | Berea High School | Gettys D Broome High School | Berea High School |
| 09/16/2022 | 7:30 PM | 5A | Berkeley High School | Fort Dorchester High School | Berkeley High School |
| 09/16/2022 | 7:30 PM | 2A | Bishop England High School | Woodland High School | Bishop England High School |
| 09/16/2022 | 7:30 PM | 4A | Bluffton High School | Battery Creek High School | Bluffton High School |
| 09/16/2022 | 7:30 PM | 3A | Brookland-Cayce High School | Chapin High School | Brookland-Cayce High School Arena |
| 09/16/2022 | 7:30 PM | 2A | Buford High School | TBA | Buford High School |
| 09/16/2022 | 7:30 PM | 1A | Burke High School | Whale Branch Early College High School | Burke High School |
| 09/16/2022 | 7:30 PM | 5A | Cane Bay High | James Island Charter High School | Cane Bay High School |
| 09/16/2022 | 7:30 PM | 5A | Carolina Forest HS | Stratford High School | Carolina Forest High School |
| 09/16/2022 | 7:30 PM | 4A | Catawba Ridge High School | Chester High School | Catawba Ridge High School |
| 09/16/2022 | 7:30 PM | 3A | Chapman High School | Clinton High School | Chapman High School |
| 09/16/2022 | 7:30 PM | 3A | Cheraw Senior High School | Marion High School | Cheraw Senior High School |
| 09/16/2022 | 7:30 PM | 2A | Chesnee High School | Woodruff High School | Chesnee High School |
| 09/16/2022 | 7:30 PM | 2A | Chesterfield High School | Blacksburg High School | Chesterfield High School |
| 09/16/2022 | 7:30 PM | 2A | Christ Church Episcopal School | Calhoun Falls High School | Christ Church Episcopal School |
| 09/16/2022 | 7:30 PM | 5A | Clover High School | Dorman High School | Clover High School |
| 09/16/2022 | 7:30 PM | 4A | Colleton County | North Charleston High School | Colleton County High School |
| 09/16/2022 | 7:30 PM | 2A | Columbia High School | Mid-carolina High School | Bolden Stadium |
| 09/16/2022 | 7:30 PM | 3A | Crescent High School | Abbeville High School | Crescent High School |
| 09/16/2022 | 7:30 PM | 3A | Crestwood High School | North Central High School | Sumter Dist. 2 – Sta |
| 09/16/2022 | 7:30 PM | 3A | D W Daniel High School | Pickens High School | D W Daniel High School |
| 09/16/2022 | 7:30 PM | 3A | Darlington High School | Wilson High School | Darlington High School |
| 09/16/2022 | 7:30 PM | 1A | Denmark-Olar High School | Blackville-hilda High School | Denmark-Olar High School |
| 09/16/2022 | 7:30 PM | 1A | Dixie High School | Mc Cormick High School | Dixie High School |
| 09/16/2022 | 7:30 PM | 5A | Easley High School | Woodmont High School | Easley High School |
| 09/16/2022 | 7:30 PM | 2A | Edisto High School | Branchville Middle High School | Edisto High School |
| 09/16/2022 | 7:30 PM | 2A | Fox Creek High School | Airport High School | North Augusta Rec Center |
| 09/16/2022 | 7:30 PM | 3A | Georgetown High School | Lake City High School | Georgetown High School |
| 09/16/2022 | 7:30 PM | 5A | Goose Creek High School | Blythewood High School | Goose Creek High School |
| 09/16/2022 | 7:30 PM | 2A | Gray Collegiate Academy | Eau Claire High School | Midland Dixie Youth Compex |
| 09/16/2022 | 7:30 PM | 1A | Green Sea Floyds High School | Carvers Bay High School | Green Sea Floyds High School |
| 09/16/2022 | 7:30 PM | 4A | Greenwood High School | T L Hanna High School | Greenwood High School |
| 09/16/2022 | 7:30 PM | 5A | Greer Senior High School | Boiling Springs High School | Greer HS Stadium |
| 09/16/2022 | 7:30 PM | 1A | Hannah-pamplico High School | East Clarendon High School | Hannah-Pamplico High School |
| 09/16/2022 | 7:30 PM | 3A | Hilton Head High School | Wade Hampton High School (Hampton) | Hilton Head High School |
| 09/16/2022 | 7:30 PM | 5A | Irmo High School | Hartsville High School | Irmo High School |
| 09/16/2022 | 7:30 PM | 5A | J L Mann High School | Greenville Sr High School | JL Mann High School |
| 09/16/2022 | 7:30 PM | 1A | Johnsonville High School | Latta High School | Johnsonville High School |
| 09/16/2022 | 7:30 PM | 2A | Kingstree Senior High School | Hemingway High School | Kingstree Senior High School |
| 09/16/2022 | 7:30 PM | 2A | Lake Marion High School & Technology Center | Cross High School | Lake Marion High School |
| 09/16/2022 | 7:30 PM | 1A | Lake View High School | Central High School | Lake View High School |
| 09/16/2022 | 7:30 PM | 1A | Lamar High School | Mc Bee High School | Lamar High School |
| 09/16/2022 | 7:30 PM | 2A | Landrum High School | spartanburg Christian | Landrum High School |
| 09/16/2022 | 7:30 PM | 4A | Laurens District 55 High School | Union High School | Laurens District 55 High School |
| 09/16/2022 | 7:30 PM | 5A | Lexington High School | Gilbert High School | Lexington High School |
| 09/16/2022 | 7:30 PM | 3A | Loris High School | Conway High School | Loris High School |
| 09/16/2022 | 7:30 PM | 4A | Lugoff-elgin High School | Fort Mill High School | Lugoff-Elgin High School |
| 09/16/2022 | 7:30 PM | 3A | Marlboro County High School | Ridgeland | Marlboro County High School |
| 09/16/2022 | 7:30 PM | 3A | May River High School – Squad 1 | Beaufort High School | May River High School |
| 09/16/2022 | 7:30 PM | 4A | Midland Valley High School | Westwood High School | Midland Valley HS |
| 09/16/2022 | 7:30 PM | 4A | North Augusta High School | Dutch Fork High School | North Augusta High School |
| 09/16/2022 | 7:30 PM | 5A | Northwestern High School | Gaffney High School | Northwestern High School |
| 09/16/2022 | 7:30 PM | 3A | Pendleton High School | Fountain Inn High School | Pendleton High School |
| 09/16/2022 | 7:30 PM | 3A | Philip Simmons High School | Aynor High School | Philip Simmons High School |
| 09/16/2022 | 7:30 PM | 3A | Powdersville High School | Hillcrest High School | Powdersville High School |
| 09/16/2022 | 7:30 PM | 5A | R B Stall High School | Lucy Beckham High School | Charleston D 4 Stadium |
| 09/16/2022 | 7:30 PM | 4A | Richland Northeast High School | Spring Valley High School | Richland Northeast High School |
| 09/16/2022 | 7:30 PM | 4A | Ridge View High School | Dreher High School | Ridge View High School |
| 09/16/2022 | 7:30 PM | 5A | River Bluff High School | Lower Richland High School | River Bluff High School |
| 09/16/2022 | 7:30 PM | 2A | Silver Bluff High School | Orangeburg-wilkinson High School | Silver Bluff High School |
| 09/16/2022 | 7:30 PM | 5A | Socastee High School | Dillon High School | Socastee High School |
| 09/16/2022 | 7:30 PM | 4A | South Aiken High School | White Knoll High School | South Aiken High School |
| 09/16/2022 | 7:30 PM | 4A | South Florence | South Pointe High School | South Florence High School |
| 09/16/2022 | 7:30 PM | 3A | Southside High School | Carolina High School | Southside High School Court – MAIN GYM |
| 09/16/2022 | 7:30 PM | 5A | Spartanburg High School | Riverside High School | Spartanburg High School |
| 09/16/2022 | 7:30 PM | 1A | St. John’s High School | Scott’s Branch | St. John’s High School |
| 09/16/2022 | 7:30 PM | 2A | St. Joseph High School | Ware Shoals High School | St. Joseph High School |
| 09/16/2022 | 7:30 PM | 5A | Sumter High School | Summerville High School | Sumter-Memorial Sta |
| 09/16/2022 | 7:30 PM | 3A | Swansea High School | C A Johnson High School | Swansea High School |
| 09/16/2022 | 7:30 PM | 2A | Timberland High School | Hanahan High School | Timberland High School |
| 09/16/2022 | 7:30 PM | 3A | Travelers Rest High School | Eastside High School | Travelers Rest High School |
| 09/16/2022 | 7:30 PM | 3A | W J Keenan High School | Fairfield Central High School | Keenan High School |
| 09/16/2022 | 7:30 PM | 3A | Waccamaw High School | Andrews High School | Waccamaw High School |
| 09/16/2022 | 7:30 PM | 4A | Wade Hampton High School (Greenville) | Blue Ridge High School | Wade Hampton High School (G) |
| 09/16/2022 | 7:30 PM | 1A | Wagener-salley High School | Hunter-kinard-tyler Middle High School | Wagener-Salley High School |
| 09/16/2022 | 7:30 PM | 3A | Walhalla Senior High School | Palmetto High School | Walhalla High School |
| 09/16/2022 | 7:30 PM | 5A | Wando High School | West Ashley High School | Wando High School Stadium |
| 09/16/2022 | 7:30 PM | 4A | Westside High School | Mauldin High School | Westside High School |
| 09/16/2022 | 7:30 PM | 1A | Williston-elko High School | Calhoun County High School | Williston-Elko High School |
| 09/16/2022 | 7:30 PM | 3A | Wren High School | James Byrnes High School | Wren High School |
| 09/16/2022 | 7:30 PM | 4A | York Comprehensive High School | Rock Hill High School | York High School |
| 09/17/2022 | 6:00 PM | 1A | Bowman High School | Military Magnet Academy | Bethune-Bowman Middle/High School |
| 09/17/2022 | 7:30 PM | 2A | Oceanside Collegiate Academy | Legion Collegiate Academy | The Citadel |
| 09/23/2022 | 7:00 PM | 1A | Ridge Spring-Monetta High School | Williston-elko High School | Ridge Spring-Monetta High School |
| 09/23/2022 | 7:30 PM | 2A | Academic Magnet High School | Northwoods Collegiate School | Charleston District 4 Stadium |
| 09/23/2022 | 7:30 PM | 4A | Airport High School | Irmo High School | Airport High School |
| 09/23/2022 | 7:30 PM | 2A | Andrews High School | Green Sea Floyds High School | Andrews High School |
| 09/23/2022 | 7:30 PM | 5A | Ashley Ridge High | Wando High School | Ashley Ridge High School |
| 09/23/2022 | 7:30 PM | 3A | Battery Creek High School | Whale Branch Early College High School | Battery Creek High School |
| 09/23/2022 | 7:30 PM | 3A | Beaufort High School | Bluffton High School | Beaufort High School |
| 09/23/2022 | 7:30 PM | 3A | Belton-honea Path High School | Walhalla Senior High School | Belton-Honea Path High School |
| 09/23/2022 | 7:30 PM | 2A | Bishop England High School | Philip Simmons High School | Bishop England High School |
| 09/23/2022 | 7:30 PM | 1A | Blackville-hilda High School | Wagener-salley High School | Blackville-Hilda High School |
| 09/23/2022 | 7:30 PM | 3A | Blue Ridge High School | Landrum High School | Blue Ridge High School |
| 09/23/2022 | 7:30 PM | 1A | Branchville Middle High School | Scott’s Branch | Branchville High School |
| 09/23/2022 | 7:30 PM | 1A | C A Johnson High School | Hemingway High School | Bolden Stadium |
| 09/23/2022 | 7:30 PM | 1A | Calhoun County High School | Hunter-kinard-tyler Middle High School | Calhoun County High School |
| 09/23/2022 | 7:30 PM | 1A | Calhoun Falls High School | West Oak High School | Calhoun Falls High School |
| 09/23/2022 | 7:30 PM | 5A | Carolina Forest HS | North Myrtle Beach High School | Carolina Forest High School |
| 09/23/2022 | 7:30 PM | 5A | Chapin High School | A C Flora High School | Chapin High School |
| 09/23/2022 | 7:30 PM | 3A | Chester High School | Batesburg-leesville High School | Chester High School |
| 09/23/2022 | 7:30 PM | 3A | Clinton High School | South Aiken High School | Clinton Middle School |
| 09/23/2022 | 7:30 PM | 5A | Clover High School | Boiling Springs High School | Clover High School |
| 09/23/2022 | 7:30 PM | 4A | Colleton County | Woodland High School | Colleton County High School |
| 09/23/2022 | 7:30 PM | 5A | Conway High School | Aynor High School | Conway High School |
| 09/23/2022 | 7:30 PM | 1A | Cross High School | Buford High School | Cross High School |
| 09/23/2022 | 7:30 PM | 3A | D W Daniel High School | Riverside High School | D W Daniel High School |
| 09/23/2022 | 7:30 PM | 3A | Dillon High School | Marlboro County High School | Dillon High School |
| 09/23/2022 | 7:30 PM | 5A | Dorman High School | River Bluff High School | Dorman High School |
| 09/23/2022 | 7:30 PM | 5A | Dutch Fork High School | TBA | Dutch Fork High School |
| 09/23/2022 | 7:30 PM | 2A | Eau Claire High School | Columbia High School | Keenan High School |
| 09/23/2022 | 7:30 PM | 2A | Edisto High School | Military Magnet Academy | Edisto High School |
| 09/23/2022 | 7:30 PM | 3A | Emerald High School | Crescent High School | Emerald High School |
| 09/23/2022 | 7:30 PM | 5A | Fort Mill High School | York Comprehensive High School | Fort Mill High School |
| 09/23/2022 | 7:30 PM | 2A | Fox Creek High School | Augusta Christian School | North Augusta Rec Center |
| 09/23/2022 | 7:30 PM | 5A | Gaffney High School | Fort Dorchester High School | Gaffney High School |
| 09/23/2022 | 7:30 PM | 5A | Goose Creek High School | Summerville High School | Goose Creek High School |
| 09/23/2022 | 7:30 PM | 2A | Gray Collegiate Academy | Mid-carolina High School | Midland Dixie Youth Compex |
| 09/23/2022 | 7:30 PM | 1A | Great Falls High School | TBA | Great Falls High School |
| 09/23/2022 | 7:30 PM | 3A | Hanahan High School | Porter-gaud School | Hanahan High School |
| 09/23/2022 | 7:30 PM | 1A | Hannah-pamplico High School | Johnsonville High School | Hannah-Pamplico High School |
| 09/23/2022 | 7:30 PM | 5A | Hillcrest High School | Wren High School | Hillcrest High School |
| 09/23/2022 | 7:30 PM | 4A | Indian Land High School | Parkwood High School | Indian Land High School |
| 09/23/2022 | 7:30 PM | 5A | J L Mann High School | Wade Hampton High School (Greenville) | JL Mann High School |
| 09/23/2022 | 7:30 PM | 2A | Kingstree Senior High School | Lamar High School | Kingstree Senior High School |
| 09/23/2022 | 7:30 PM | 3A | Lake City High School | Camden High School | Lake City High School |
| 09/23/2022 | 7:30 PM | 1A | Latta High School | Cheraw Senior High School | Buddy Johnson Park – Latta |
| 09/23/2022 | 7:30 PM | 4A | Laurens District 55 High School | T L Hanna High School | Laurens District 55 High School |
| 09/23/2022 | 7:30 PM | 1A | Lewisville High School | Andrew Jackson High School | Lewisville High School |
| 09/23/2022 | 7:30 PM | 2A | Liberty High School | Pickens High School | Liberty HS |
| 09/23/2022 | 7:30 PM | 3A | Loris High School | Lake View High School | Loris High School |
| 09/23/2022 | 7:30 PM | 3A | Manning High School | Baptist Hill High School | Manning High School |
| 09/23/2022 | 7:30 PM | 4A | May River High School – Squad 1 | Cane Bay High | May River High School |
| 09/23/2022 | 7:30 PM | 1A | Mc Bee High School | Chesterfield High School | Mc Bee High School |
| 09/23/2022 | 7:30 PM | 1A | Mc Cormick High School | Christ Church Episcopal School | McCormick High School |
| 09/23/2022 | 7:30 PM | 2A | Mullins High School | Carvers Bay High School | Mullins High School |
| 09/23/2022 | 7:30 PM | 4A | Myrtle Beach High School | Marion High School | Myrtle Beach High School |
| 09/23/2022 | 7:30 PM | 5A | Nation Ford High School | Richland Northeast High School | Nation Ford HS |
| 09/23/2022 | 7:30 PM | 2A | Newberry High School | W J Keenan High School | Newberry High School |
| 09/23/2022 | 7:30 PM | 3A | North Charleston High School | Burke High School | Burke High School |
| 09/23/2022 | 7:30 PM | 2A | Oceanside Collegiate Academy | Sumter High School | Oceanside Collegiate Academy |
| 09/23/2022 | 7:30 PM | 2A | Pelion High School | Ninety Six High School | Pelion High School |
| 09/23/2022 | 7:30 PM | 3A | Pendleton High School | Palmetto High School | Pendleton High School |
| 09/23/2022 | 7:30 PM | 2A | Saluda High School | Gilbert High School | Saluda High School |
| 09/23/2022 | 7:30 PM | 2A | Silver Bluff High School | Barnwell High School | Silver Bluff High School |
| 09/23/2022 | 7:30 PM | 1A | Southside Christian School | St. Joseph High School | Southside Christian School |
| 09/23/2022 | 7:30 PM | 3A | Southside High School | Easley High School | Southside High School Court – MAIN GYM |
| 09/23/2022 | 7:30 PM | 5A | Spartanburg High School | Mauldin High School | Spartanburg High School |
| 09/23/2022 | 7:30 PM | 5A | St. James High School | Stratford High School | St. James High School |
| 09/23/2022 | 7:30 PM | 3A | Strom Thurmond High School | North Augusta High School | Strom Thurmond H |
| 09/23/2022 | 7:30 PM | 3A | Swansea High School | Midland Valley High School | Swansea High School |
| 09/23/2022 | 7:30 PM | 3A | Travelers Rest High School | Berea High School | Travelers Rest High School |
| 09/23/2022 | 7:30 PM | 3A | Union High School | Chapman High School | Union High School |
| 09/23/2022 | 7:30 PM | 2A | Wade Hampton High School (Hampton) | Bamberg-Ehrhardt High School | Wade Hampton High School (H) |
| 09/23/2022 | 7:30 PM | 1A | Ware Shoals High School | Dixie High School | Ware Shoals High School |
| 09/23/2022 | 7:30 PM | 5A | West Ashley High School | Timberland High School | West Ashley High School |
| 09/23/2022 | 7:30 PM | 4A | West Florence High School | TBA | West Florence High School |
| 09/23/2022 | 7:30 PM | 4A | Westside High School | Greer Senior High School | Westside High School |
| 09/23/2022 | 7:30 PM | 5A | White Knoll High School | Lancaster High School | White Knoll High School |
| 09/23/2022 | 7:30 PM | 1A | Whitmire High School | Carolina High School | Whitmire High School |
| 09/23/2022 | 7:30 PM | 5A | Woodmont High School | Seneca | Woodmont High School |
| 09/23/2022 | 7:30 PM | 3A | Woodruff High School | Gettys D Broome High School | Woodruff High School |
| 09/26/2022 | 7:30 PM | 2A | Lee Central High | Estill High School | Lee Central High School |
| 09/29/2022 | 6:00 PM | 5A | R B Stall High School | West Ashley | Charleston D 4 Stadium |
| 09/30/2022 | 7:30 PM | 2A | Abbeville High School | Liberty High School | Abbeville High School |
| 09/30/2022 | 7:30 PM | 4A | Airport High School | Aiken High School | Airport High School |
| 09/30/2022 | 7:30 PM | 1A | Allendale-fairfax High School | Branchville Middle High School | Allendale Fairfax High School |
| 09/30/2022 | 7:30 PM | 2A | Andrew Jackson High School | Cheraw Senior High School | Andrew Jackson High School |
| 09/30/2022 | 7:30 PM | 2A | Andrews High School | Marion High School | Andrews High School |
| 09/30/2022 | 7:30 PM | 5A | Ashley Ridge High | Fort Dorchester High School | Ashley Ridge High School |
| 09/30/2022 | 7:30 PM | 2A | Barnwell High School | Edisto High School | Barnwell High School |
| 09/30/2022 | 7:30 PM | 3A | Battery Creek High School | North Charleston High School | Battery Creek High School |
| 09/30/2022 | 7:30 PM | 3A | Beaufort High School | Philip Simmons High School | Beaufort High School |
| 09/30/2022 | 7:30 PM | 5A | Berkeley High School | Goose Creek High School | Berkeley High School |
| 09/30/2022 | 7:30 PM | 2A | Bishop England High School | Timberland High School | Bishop England High School |
| 09/30/2022 | 7:30 PM | 5A | Blythewood High School | Fort Mill High School | Blythewood High School |
| 09/30/2022 | 7:30 PM | 5A | Boiling Springs High School | Dorman High School | Boiling Springs High School |
| 09/30/2022 | 7:30 PM | 1A | Burke High School | Military Magnet Academy | Burke High School |
| 09/30/2022 | 7:30 PM | 3A | Camden High School | Lakewood High School | Camden City Arena |
| 09/30/2022 | 7:30 PM | 2A | Central High School | Buford High School | Central High School |
| 09/30/2022 | 7:30 PM | 5A | Chapin High School | Lexington High School | Chapin High School |
| 09/30/2022 | 7:30 PM | 3A | Chapman High School | Carolina High School | Chapman High School |
| 09/30/2022 | 7:30 PM | 3A | Chester High School | Woodruff High School | Chester High School |
| 09/30/2022 | 7:30 PM | 5A | Clover High School | Nation Ford High School | Clover High School |
| 09/30/2022 | 7:30 PM | 4A | Colleton County | James Island Charter High School | Colleton County High School |
| 09/30/2022 | 7:30 PM | 2A | Columbia High School | Gray Collegiate Academy | Bolden Stadium |
| 09/30/2022 | 7:30 PM | 5A | Conway High School | St. James High School | Conway High School |
| 09/30/2022 | 7:30 PM | 3A | Crestwood High School | Lake City High School | Sumter Dist. 2 – Sta |
| 09/30/2022 | 7:30 PM | 1A | Cross High School | St. John’s High School | Cross High School |
| 09/30/2022 | 7:30 PM | 3A | Darlington High School | Marlboro County High School | Darlington High School |
| 09/30/2022 | 7:30 PM | 1A | Denmark-Olar High School | Ridge Spring-Monetta High School | Denmark-Olar High School |
| 09/30/2022 | 7:30 PM | 3A | Dreher High School | Swansea High School | Memorial Stadium-Columbia |
| 09/30/2022 | 7:30 PM | 1A | East Clarendon High School | Hemingway High School | East Clarendon High School |
| 09/30/2022 | 7:30 PM | 4A | Eastside High School | Emerald High School | Eastside High School |
| 09/30/2022 | 7:30 PM | 1A | Estill High School | Bamberg-Ehrhardt High School | Estill High School |
| 09/30/2022 | 7:30 PM | 3A | Fountain Inn High School | Wren High School | Fountain Inn High School |
| 09/30/2022 | 7:30 PM | 2A | Fox Creek High School | Silver Bluff High School | North Augusta Rec Center |
| 09/30/2022 | 7:30 PM | 3A | Georgetown High School | Waccamaw High School | Georgetown High School |
| 09/30/2022 | 7:30 PM | 1A | Great Falls High School | Whitmire High School | Great Falls High School |
| 09/30/2022 | 7:30 PM | 1A | Green Sea Floyds High School | Lake View High School | Green Sea Floyds High School |
| 09/30/2022 | 7:30 PM | 4A | Greenwood High School | Berea High School | Greenwood High School |
| 09/30/2022 | 7:30 PM | 5A | Greer Senior High School | Laurens District 55 High School | Greer HS Stadium |
| 09/30/2022 | 7:30 PM | 4A | Hartsville High School | South Florence High School | Hartsville High School |
| 09/30/2022 | 7:30 PM | 4A | Hilton Head High School | Bluffton High School | Hilton Head High School |
| 09/30/2022 | 7:30 PM | 5A | J L Mann High School | Woodmont High School | JL Mann High School |
| 09/30/2022 | 7:30 PM | 1A | Johnsonville High School | Carvers Bay High School | Johnsonville High School |
| 09/30/2022 | 7:30 PM | 2A | Landrum High School | Chesnee High School | Landrum High School |
| 09/30/2022 | 7:30 PM | 1A | Latta High School | Lamar High School | Buddy Johnson Park – Latta |
| 09/30/2022 | 7:30 PM | 2A | Lee Central High | Mullins High School | Lee Central High School |
| 09/30/2022 | 7:30 PM | 1A | Lewisville High School | C A Johnson High School | Lewisville High School |
| 09/30/2022 | 7:30 PM | 3A | Loris High School | Dillon High School | Loris High School |
| 09/30/2022 | 7:30 PM | 3A | Lower Richland High School | Gilbert High School | Lower Richland High School |
| 09/30/2022 | 7:30 PM | 3A | Manning High School | Aynor High School | Manning High School |
| 09/30/2022 | 7:30 PM | 5A | Mauldin High School | T L Hanna High School | Mauldin High School |
| 09/30/2022 | 7:30 PM | 4A | May River High School – Squad 1 | Lucy Beckham High School | May River High School |
| 09/30/2022 | 7:30 PM | 2A | Mid-carolina High School | Fairfield Central High School | Mid Carolina High School |
| 09/30/2022 | 7:30 PM | 4A | Myrtle Beach High School | West Florence High School | Myrtle Beach High School |
| 09/30/2022 | 7:30 PM | 2A | Newberry High School | Eau Claire High School | Newberry High School |
| 09/30/2022 | 7:30 PM | 2A | Ninety Six High School | Blacksburg High School | Ninety Six High School |
| 09/30/2022 | 7:30 PM | 2A | North Central High School | Chesterfield High School | North Central High School |
| 09/30/2022 | 7:30 PM | 4A | Northwestern High School | Lancaster High School | Northwestern High School |
| 09/30/2022 | 7:30 PM | 2A | Oceanside Collegiate Academy | Lake Marion High School & Technology Center | The Citadel |
| 09/30/2022 | 7:30 PM | 3A | Orangeburg-wilkinson High School | Brookland-Cayce High School | Orangeburg-Wilkinson High School |
| 09/30/2022 | 7:30 PM | 4A | Pickens High School | Easley High School | Pickens High School |
| 09/30/2022 | 7:30 PM | 3A | Powdersville High School | Belton-honea Path High School | Powdersville High School |
| 09/30/2022 | 7:30 PM | 4A | Richland Northeast High School | Irmo High School | Richland Northeast High School |
| 09/30/2022 | 7:30 PM | 4A | Ridge View High School | Lugoff-elgin High School | Ridge View High School |
| 09/30/2022 | 7:30 PM | 4A | Riverside High School | Wade Hampton High School (Greenville) | Riverside High School |
| 09/30/2022 | 7:30 PM | 2A | Saluda High School | Pelion High School | Saluda High School |
| 09/30/2022 | 7:30 PM | 1A | Scott’s Branch | Calhoun Falls High School | Scott’s Branch HS |
| 09/30/2022 | 7:30 PM | 3A | Seneca | Crescent High School | Seneca High |
| 09/30/2022 | 7:30 PM | 5A | Socastee High School | Sumter High School | Socastee High School |
| 09/30/2022 | 7:30 PM | 4A | South Aiken High School | North Augusta High School | South Aiken High School |
| 09/30/2022 | 7:30 PM | 4A | South Pointe High School | Catawba Ridge High School | South Pointe High School |
| 09/30/2022 | 7:30 PM | 1A | Southside Christian School | Dixie High School | Southside Christian School |
| 09/30/2022 | 7:30 PM | 3A | Southside High School | Palmetto High School | Southside High School Court – MAIN GYM |
| 09/30/2022 | 7:30 PM | 5A | Spartanburg High School | James Byrnes High School | Spartanburg High School |
| 09/30/2022 | 7:30 PM | 5A | Spring Valley High School | Rock Hill High School | Spring Valley High School |
| 09/30/2022 | 7:30 PM | 3A | Strom Thurmond High School | Batesburg-leesville High School | Strom Thurmond H |
| 09/30/2022 | 7:30 PM | 5A | Summerville High School | Stratford High School | Summerville-Memorial Sta. |
| 09/30/2022 | 7:30 PM | 3A | Travelers Rest High School | Gettys D Broome High School | Travelers Rest High School |
| 09/30/2022 | 7:30 PM | 3A | Union High School | Clinton High School | Union High School |
| 09/30/2022 | 7:30 PM | 2A | Wade Hampton High School (Hampton) | Ridgeland | Wade Hampton High School (H) |
| 09/30/2022 | 7:30 PM | 3A | Walhalla Senior High School | D W Daniel High School | Walhalla High School |
| 09/30/2022 | 7:30 PM | 5A | Wando High School | Cane Bay High | Wando High School Stadium |
| 09/30/2022 | 7:30 PM | 1A | Ware Shoals High School | Mc Cormick High School | Ware Shoals High School |
| 09/30/2022 | 7:30 PM | 5A | West Ashley High School | R B Stall High School | West Ashley High School |
| 09/30/2022 | 7:30 PM | 3A | West Oak High School | Pendleton High School | West Oak High School |
| 09/30/2022 | 7:30 PM | 4A | Westside High School | Greenville Sr High School | Westside High School |
| 09/30/2022 | 7:30 PM | 4A | Westwood High School | A C Flora High School | Westwood High School |
| 09/30/2022 | 7:30 PM | 1A | Whale Branch Early College High School | Bowman High School | Whale Branch Early College High School |
| 09/30/2022 | 7:30 PM | 5A | White Knoll High School | River Bluff High School | White Knoll High School |
| 09/30/2022 | 7:30 PM | 1A | Williston-elko High School | Wagener-salley High School | Williston-Elko High School |
| 09/30/2022 | 7:30 PM | 4A | Wilson High School | North Myrtle Beach High School | Wilson High School |
| 09/30/2022 | 7:30 PM | 2A | Woodland High School | Hanahan High School | Woodland High School |
| 09/30/2022 | 7:30 PM | 4A | York Comprehensive High School | Indian Land High School | York High School |
| 09/30/2022 | 8:00 PM | 1A | Hunter-kinard-tyler Middle High School | Blackville-hilda High School | Hunter-Kinard-Tyler High School |
| 10/06/2022 | 7:00 PM | 5A | J L Mann High School – JV | T L Hanna High School | J. L. Mann HS Sports Complex |
| 10/06/2022 | 7:00 PM | 2A | Pelion High School | Fox Creek High School | Pelion High School |
| 10/06/2022 | 7:30 PM | 3A | North Charleston High School | Hanahan High School | Charleston D 4 Stadium |
| 10/07/2022 | 7:00 PM | 1A | Ridge Spring-Monetta High School | Blackville-hilda High School | Ridge Spring-Monetta High School |
| 10/07/2022 | 7:00 PM | 5A | St. James High School | Socastee High School | St. James High School |
| 10/07/2022 | 7:30 PM | 4A | A C Flora High School | Richland Northeast High School | A C Flora High School |
| 10/07/2022 | 7:30 PM | 4A | Aiken High School | North Augusta High School | Aiken High School |
| 10/07/2022 | 7:30 PM | 5A | Ashley Ridge High | West Ashley High School | Ashley Ridge High School |
| 10/07/2022 | 7:30 PM | 1A | Baptist Hill High School | Military Magnet Academy | Baptist Hill High School |
| 10/07/2022 | 7:30 PM | 2A | Batesburg-leesville High School | Silver Bluff High School | Batesburg-Leesville High School |
| 10/07/2022 | 7:30 PM | 4A | Bluffton High School | Lucy Beckham High School | Bluffton High School |
| 10/07/2022 | 7:30 PM | 1A | Bowman High School | Allendale-fairfax High School | Bethune-Bowman Middle/High School |
| 10/07/2022 | 7:30 PM | 1A | Branchville Middle High School | Bamberg-Ehrhardt High School | Branchville High School |
| 10/07/2022 | 7:30 PM | 3A | Brookland-Cayce High School | Lower Richland High School | Brookland-Cayce High School Arena |
| 10/07/2022 | 7:30 PM | 2A | Buford High School | North Central High School | Buford High School |
| 10/07/2022 | 7:30 PM | 1A | C A Johnson High School | Great Falls High School | Bolden Stadium |
| 10/07/2022 | 7:30 PM | 1A | Calhoun County High School | Denmark-Olar High School | Calhoun County High School |
| 10/07/2022 | 7:30 PM | 5A | Cane Bay High | Stratford High School | Cane Bay High School |
| 10/07/2022 | 7:30 PM | 5A | Carolina Forest HS | Conway High School | Carolina Forest High School |
| 10/07/2022 | 7:30 PM | 3A | Carolina High School | Travelers Rest High School | Carolina High School |
| 10/07/2022 | 7:30 PM | 1A | Carvers Bay High School | Hemingway High School | Carvers Bay High School |
| 10/07/2022 | 7:30 PM | 4A | Catawba Ridge High School | York Comprehensive High School | Catawba Ridge High School |
| 10/07/2022 | 7:30 PM | 3A | Cheraw Senior High School | Central High School | Cheraw Senior High School |
| 10/07/2022 | 7:30 PM | 2A | Chesnee High School | Abbeville High School | Chesnee High School |
| 10/07/2022 | 7:30 PM | 2A | Chesterfield High School | Andrew Jackson High School | Chesterfield High School |
| 10/07/2022 | 7:30 PM | 3A | D W Daniel High School | West Oak High School | D W Daniel High School |
| 10/07/2022 | 7:30 PM | 3A | Darlington High School | Camden High School | Darlington High School |
| 10/07/2022 | 7:30 PM | 3A | Dillon High School | Aynor High School | Dillon High School |
| 10/07/2022 | 7:30 PM | 1A | Dixie High School | St. Joseph High School | Dixie High School |
| 10/07/2022 | 7:30 PM | 5A | Dutch Fork High School | White Knoll High School | Dutch Fork High School |
| 10/07/2022 | 7:30 PM | 4A | Eastside High School | Greer Senior High School | Eastside High School |
| 10/07/2022 | 7:30 PM | 2A | Edisto High School | Wade Hampton High School (Hampton) | Edisto High School |
| 10/07/2022 | 7:30 PM | 3A | Fairfield Central High School | Gray Collegiate Academy | Fairfield Central High School |
| 10/07/2022 | 7:30 PM | 5A | Fort Dorchester High School | Goose Creek High School | Fort Dorchester High School |
| 10/07/2022 | 7:30 PM | 5A | Gaffney High School | Spartanburg High School | Gaffney High School |
| 10/07/2022 | 7:30 PM | 3A | Georgetown High School | Manning High School | Georgetown High School |
| 10/07/2022 | 7:30 PM | 3A | Gettys D Broome High School | Blue Ridge High School | Gettys D. Broome High School |
| 10/07/2022 | 7:30 PM | 3A | Gilbert High School | Swansea High School | Gilbert High School |
| 10/07/2022 | 7:30 PM | 4A | Greenville Sr High School | Berea High School | G’ville’s – Sirrine Sta |
| 10/07/2022 | 7:30 PM | 4A | Greenwood High School | Easley High School | Greenwood High School |
| 10/07/2022 | 7:30 PM | 1A | Hannah-pamplico High School | Latta High School | Hannah-Pamplico High School |
| 10/07/2022 | 7:30 PM | 4A | Hartsville High School | Myrtle Beach High School | Hartsville High School |
| 10/07/2022 | 7:30 PM | 5A | Hillcrest High School | Woodmont High School | Hillcrest High School |
| 10/07/2022 | 7:30 PM | 4A | Hilton Head High School | Colleton County | Hilton Head High School |
| 10/07/2022 | 7:30 PM | 4A | Indian Land High School | Northwestern High School | Indian Land High School |
| 10/07/2022 | 7:30 PM | 5A | Irmo High School | Ridge View High School | Irmo High School |
| 10/07/2022 | 7:30 PM | 5A | James Byrnes High School | Boiling Springs High School | James F. Byrnes High School |
| 10/07/2022 | 7:30 PM | 5A | James Island Charter High School | May River High School – Squad 1 | James Island Charter High School |
| 10/07/2022 | 7:30 PM | 1A | Johnsonville High School | Scott’s Branch | Johnsonville High School |
| 10/07/2022 | 7:30 PM | 3A | Lake City High School | Lakewood High School | Lake City High School |
| 10/07/2022 | 7:30 PM | 2A | Lake Marion High School & Technology Center | Bishop England High School | Lake Marion High School |
| 10/07/2022 | 7:30 PM | 1A | Lamar High School | Green Sea Floyds High School | Lamar High School |
| 10/07/2022 | 7:30 PM | 4A | Lancaster High School | South Pointe High School | Lancaster High School |
| 10/07/2022 | 7:30 PM | 2A | Landrum High School | Ninety Six High School | Landrum High School |
| 10/07/2022 | 7:30 PM | 4A | Laurens District 55 High School | Riverside High School | Laurens District 55 High School |
| 10/07/2022 | 7:30 PM | 5A | Lexington High School | River Bluff High School | Lexington High School |
| 10/07/2022 | 7:30 PM | 2A | Liberty High School | Blacksburg High School | Liberty HS |
| 10/07/2022 | 7:30 PM | 4A | Lugoff-elgin High School | Westwood High School | Lugoff-Elgin High School |
| 10/07/2022 | 7:30 PM | 2A | Marion High School | Kingstree Senior High School | Marion High School |
| 10/07/2022 | 7:30 PM | 3A | Marlboro County High School | Crestwood High School | Marlboro County High School |
| 10/07/2022 | 7:30 PM | 5A | Mauldin High School | Dorman High School | Mauldin High School |
| 10/07/2022 | 7:30 PM | 1A | Mc Cormick High School | TBA | McCormick High School |
| 10/07/2022 | 7:30 PM | 2A | Mid-carolina High School | Newberry High School | Mid Carolina High School |
| 10/07/2022 | 7:30 PM | 4A | Midland Valley High School | Airport High School | Midland Valley HS |
| 10/07/2022 | 7:30 PM | 2A | Mullins High School | Andrews High School | Mullins High School |
| 10/07/2022 | 7:30 PM | 5A | Nation Ford High School | Blythewood High School | Nation Ford HS |
| 10/07/2022 | 7:30 PM | 4A | North Myrtle Beach High School | West Florence High School | North Myrtle Beach High School |
| 10/07/2022 | 7:30 PM | 3A | Orangeburg-wilkinson High School | Dreher High School | Orangeburg-Wilkinson High School |
| 10/07/2022 | 7:30 PM | 3A | Palmetto High School | Belton-honea Path High School | Palmetto High School |
| 10/07/2022 | 7:30 PM | 3A | Pendleton High School | Seneca | Pendleton High School |
| 10/07/2022 | 7:30 PM | 3A | Powdersville High School | Fountain Inn High School | Powdersville High School |
| 10/07/2022 | 7:30 PM | 5A | R B Stall High School | Summerville High School | Charleston D 4 Stadium |
| 10/07/2022 | 7:30 PM | 2A | Ridgeland | Woodland High School | Ridgeland-Hardeeville High School |
| 10/07/2022 | 7:30 PM | 5A | Rock Hill High School | Fort Mill High School | Rock Hill High School |
| 10/07/2022 | 7:30 PM | 2A | Saluda High School | Strom Thurmond High School | Saluda High School |
| 10/07/2022 | 7:30 PM | 4A | South Florence | Wilson High School | South Florence High School |
| 10/07/2022 | 7:30 PM | 1A | Southside Christian School | Calhoun Falls High School | Southside Christian School |
| 10/07/2022 | 7:30 PM | 5A | Spring Valley High School | Clover High School | Spring Valley High School |
| 10/07/2022 | 7:30 PM | 1A | St. John’s High School | Burke High School | St. John’s High School |
| 10/07/2022 | 7:30 PM | 5A | T L Hanna High School | J L Mann High School | T L Hanna High School |
| 10/07/2022 | 7:30 PM | 2A | Timberland High School | Academic Magnet High School | Timberland High School |
| 10/07/2022 | 7:30 PM | 3A | Union High School | Chester High School | Union High School |
| 10/07/2022 | 7:30 PM | 3A | W J Keenan High School | Columbia High School | Keenan High School |
| 10/07/2022 | 7:30 PM | 3A | Waccamaw High School | Loris High School | Waccamaw High School |
| 10/07/2022 | 7:30 PM | 3A | Walhalla Senior High School | Crescent High School | Walhalla High School |
| 10/07/2022 | 7:30 PM | 5A | Wando High School | Berkeley High School | Wando High School Stadium |
| 10/07/2022 | 7:30 PM | 1A | Ware Shoals High School | Christ Church Episcopal School | Ware Shoals High School |
| 10/07/2022 | 7:30 PM | 4A | Westside High School | Pickens High School | Westside High School |
| 10/07/2022 | 7:30 PM | 1A | Whale Branch Early College High School | Estill High School | Whale Branch Early College High School |
| 10/07/2022 | 7:30 PM | 1A | Whitmire High School | Mc Bee High School | Whitmire High School |
| 10/07/2022 | 7:30 PM | 1A | Williston-elko High School | Hunter-kinard-tyler Middle High School | Williston-Elko High School |
| 10/07/2022 | 7:30 PM | 3A | Woodruff High School | Emerald High School | Woodruff High School |
| 10/07/2022 | 7:30 PM | 3A | Wren High School | Southside High School | Wren High School |
| 10/08/2022 | 12:00 PM | 3A | Battery Creek High School | Beaufort High School | Battery Creek High School |
| 10/13/2022 | 6:00 PM | 5A | R B Stall High School | Fort Dorchester High School | Old R.B.Stall HS |
| 10/13/2022 | 7:00 PM | 5A | J L Mann High School – JV | Mauldin High School | J. L. Mann HS Sports Complex |
| 10/14/2022 | 7:00 PM | 1A | Ridge Spring-Monetta High School | Wagener-salley High School | Ridge Spring-Monetta High School |
| 10/14/2022 | 7:30 PM | 4A | A C Flora High School | Irmo High School | A C Flora High School |
| 10/14/2022 | 7:30 PM | 2A | Abbeville High School | Landrum High School | Abbeville High School |
| 10/14/2022 | 7:30 PM | 2A | Academic Magnet High School | Oceanside Collegiate Academy | Charleston Distr. 4 Stadium |
| 10/14/2022 | 7:30 PM | 4A | Airport High School | South Aiken High School | Airport High School |
| 10/14/2022 | 7:30 PM | 1A | Allendale-fairfax High School | Whale Branch Early College High School | Allendale Fairfax High School |
| 10/14/2022 | 7:30 PM | 2A | Andrews High School | Kingstree Senior High School | Andrews High School |
| 10/14/2022 | 7:30 PM | 3A | Aynor High School | Waccamaw High School | Aynor High School |
| 10/14/2022 | 7:30 PM | 1A | Bamberg-Ehrhardt High School | Bowman High School | Bamberg-Ehrhardt High School |
| 10/14/2022 | 7:30 PM | 4A | Berea High School | Easley High School | Berea High School |
| 10/14/2022 | 7:30 PM | 5A | Berkeley High School | Ashley Ridge High | Berkeley High School |
| 10/14/2022 | 7:30 PM | 2A | Blacksburg High School | Chesnee High School | Blacksburg High School |
| 10/14/2022 | 7:30 PM | 1A | Blackville-hilda High School | Calhoun County High School | Blackville-Hilda High School |
| 10/14/2022 | 7:30 PM | 3A | Blue Ridge High School | Carolina High School | Blue Ridge High School |
| 10/14/2022 | 7:30 PM | 4A | Bluffton High School | James Island Charter High School | Bluffton High School |
| 10/14/2022 | 7:30 PM | 5A | Blythewood High School | Clover High School | Blythewood High School |
| 10/14/2022 | 7:30 PM | 5A | Boiling Springs High School | Gaffney High School | Boiling Springs High School |
| 10/14/2022 | 7:30 PM | 3A | Brookland-Cayce High School | Dreher High School | Brookland-Cayce High School Arena |
| 10/14/2022 | 7:30 PM | 2A | Buford High School | Chesterfield High School | Buford High School |
| 10/14/2022 | 7:30 PM | 1A | Burke High School | Baptist Hill High School | Burke High School |
| 10/14/2022 | 7:30 PM | 1A | Calhoun Falls High School | Ware Shoals High School | Calhoun Falls High School |
| 10/14/2022 | 7:30 PM | 4A | Catawba Ridge High School | Lancaster High School | Catawba Ridge High School |
| 10/14/2022 | 7:30 PM | 2A | Central High School | Andrew Jackson High School | Central High School |
| 10/14/2022 | 7:30 PM | 2A | Christ Church Episcopal School | Dixie High School | Christ Church Episcopal School |
| 10/14/2022 | 7:30 PM | 3A | Clinton High School | Woodruff High School | Clinton Middle School |
| 10/14/2022 | 7:30 PM | 4A | Colleton County | May River High School – Squad 1 | Colleton County High School |
| 10/14/2022 | 7:30 PM | 2A | Columbia High School | Fairfield Central High School | Bolden Stadium |
| 10/14/2022 | 7:30 PM | 5A | Conway High School | Socastee High School | Conway High School |
| 10/14/2022 | 7:30 PM | 3A | Crescent High School | Pendleton High School | Crescent High School |
| 10/14/2022 | 7:30 PM | 3A | Crestwood High School | Darlington High School | Sumter Dist. 2 – Sta |
| 10/14/2022 | 7:30 PM | 1A | Denmark-Olar High School | Hunter-kinard-tyler Middle High School | Denmark-Olar High School |
| 10/14/2022 | 7:30 PM | 3A | Dillon High School | Manning High School | Dillon High School |
| 10/14/2022 | 7:30 PM | 5A | Dorman High School | James Byrnes High School | Dorman High School |
| 10/14/2022 | 7:30 PM | 5A | Dutch Fork High School | Chapin High School | Dutch Fork High School |
| 10/14/2022 | 7:30 PM | 1A | East Clarendon High School | Johnsonville High School | East Clarendon High School |
| 10/14/2022 | 7:30 PM | 4A | Eastside High School | Riverside High School | Eastside High School |
| 10/14/2022 | 7:30 PM | 2A | Eau Claire High School | W J Keenan High School | Keenan High School |
| 10/14/2022 | 7:30 PM | 3A | Emerald High School | Chester High School | Emerald High School |
| 10/14/2022 | 7:30 PM | 1A | Estill High School | Branchville Middle High School | Estill High School |
| 10/14/2022 | 7:30 PM | 5A | Fort Dorchester High School | R B Stall High School | Fort Dorchester High School |
| 10/14/2022 | 7:30 PM | 5A | Fort Mill High School | Spring Valley High School | Fort Mill High School |
| 10/14/2022 | 7:30 PM | 3A | Fountain Inn High School | Belton-honea Path High School | Fountain Inn High School |
| 10/14/2022 | 7:30 PM | 2A | Fox Creek High School | Batesburg-leesville High School | North Augusta Rec Center |
| 10/14/2022 | 7:30 PM | 3A | Gilbert High School | Orangeburg-wilkinson High School | Gilbert High School |
| 10/14/2022 | 7:30 PM | 5A | Goose Creek High School | Cane Bay High | Goose Creek High School |
| 10/14/2022 | 7:30 PM | 2A | Gray Collegiate Academy | Newberry High School | Midland Dixie Youth Compex |
| 10/14/2022 | 7:30 PM | 4A | Greenville Sr High School | Pickens High School | G’ville’s – Sirrine Sta |
| 10/14/2022 | 7:30 PM | 4A | Greenwood High School | Westside High School | Greenwood High School |
| 10/14/2022 | 7:30 PM | 3A | Hanahan High School | Battery Creek High School | Hanahan High School |
| 10/14/2022 | 7:30 PM | 1A | Hannah-pamplico High School | Lamar High School | Hannah-Pamplico High School |
| 10/14/2022 | 7:30 PM | 4A | Hartsville High School | North Myrtle Beach High School | Hartsville High School |
| 10/14/2022 | 7:30 PM | 2A | Lake Marion High School & Technology Center | Timberland High School | Lake Marion High School |
| 10/14/2022 | 7:30 PM | 1A | Lake View High School | Latta High School | Lake View High School |
| 10/14/2022 | 7:30 PM | 3A | Lakewood High School | Marlboro County High School | Lakewood High School |
| 10/14/2022 | 7:30 PM | 1A | Lewisville High School | Great Falls High School | Lewisville High School |
| 10/14/2022 | 7:30 PM | 3A | Loris High School | Georgetown High School | Loris High School |
| 10/14/2022 | 7:30 PM | 4A | Lucy Beckham High School | Hilton Head High School | Wando High School Stadium |
| 10/14/2022 | 7:30 PM | 2A | Marion High School | Lee Central High | Marion High School |
| 10/14/2022 | 7:30 PM | 5A | Mauldin High School | J L Mann High School | Mauldin High School |
| 10/14/2022 | 7:30 PM | 1A | Mc Bee High School | C A Johnson High School | Mc Bee High School |
| 10/14/2022 | 7:30 PM | 1A | Mc Cormick High School | TBA | Southside Christian School |
| 10/14/2022 | 7:30 PM | 4A | Midland Valley High School | Aiken High School | Midland Valley HS |
| 10/14/2022 | 7:30 PM | 1A | Military Magnet Academy | Cross High School | Garrett Acad. – Ayoub Sta |
| 10/14/2022 | 7:30 PM | 4A | Myrtle Beach High School | South Florence High School | Myrtle Beach High School |
| 10/14/2022 | 7:30 PM | 5A | Nation Ford High School | Rock Hill High School | Nation Ford HS |
| 10/14/2022 | 7:30 PM | 2A | Ninety Six High School | Liberty High School | Ninety Six High School |
| 10/14/2022 | 7:30 PM | 2A | North Central High School | Cheraw Senior High School | North Central High School |
| 10/14/2022 | 7:30 PM | 4A | Northwestern High School | York Comprehensive High School | Northwestern High School |
| 10/14/2022 | 7:30 PM | 3A | Philip Simmons High School | North Charleston High School | Philip Simmons High School |
| 10/14/2022 | 7:30 PM | 4A | Richland Northeast High School | Lugoff-elgin High School | Richland Northeast High School |
| 10/14/2022 | 7:30 PM | 2A | Ridgeland | Barnwell High School | Ridgeland-Hardeeville High School |
| 10/14/2022 | 7:30 PM | 1A | Scott’s Branch | Carvers Bay High School | Scott’s Branch HS |
| 10/14/2022 | 7:30 PM | 3A | Seneca | D W Daniel High School | Seneca High |
| 10/14/2022 | 7:30 PM | 2A | Silver Bluff High School | Saluda High School | Silver Bluff High School |
| 10/14/2022 | 7:30 PM | 4A | South Pointe High School | Indian Land High School | South Pointe High School |
| 10/14/2022 | 7:30 PM | 3A | Southside High School | Powdersville High School | Southside High School Court – MAIN GYM |
| 10/14/2022 | 7:30 PM | 5A | Stratford High School | Wando High School | Stratford High School |
| 10/14/2022 | 7:30 PM | 3A | Strom Thurmond High School | Pelion High School | Strom Thurmond H |
| 10/14/2022 | 7:30 PM | 5A | Summerville High School | West Ashley High School | Summerville-Memorial Sta. |
| 10/14/2022 | 7:30 PM | 5A | Sumter High School | Carolina Forest HS | Sumter-Memorial Sta |
| 10/14/2022 | 7:30 PM | 3A | Swansea High School | Lower Richland High School | Swansea High School |
| 10/14/2022 | 7:30 PM | 5A | T L Hanna High School | Hillcrest High School | T L Hanna High School |
| 10/14/2022 | 7:30 PM | 3A | Travelers Rest High School | Chapman High School | Travelers Rest High School |
| 10/14/2022 | 7:30 PM | 4A | Wade Hampton High School (Greenville) | Laurens District 55 High School | Wade Hampton High School (G) |
| 10/14/2022 | 7:30 PM | 4A | West Florence High School | Wilson High School | West Florence High School |
| 10/14/2022 | 7:30 PM | 3A | West Oak High School | Walhalla Senior High School | West Oak High School |
| 10/14/2022 | 7:30 PM | 4A | Westwood High School | Ridge View High School | Westwood High School |
| 10/14/2022 | 7:30 PM | 5A | White Knoll High School | Lexington High School | White Knoll High School |
| 10/14/2022 | 7:30 PM | 1A | Williston-elko High School | Whitmire High School | Williston-Elko High School |
| 10/14/2022 | 7:30 PM | 2A | Woodland High School | Wade Hampton High School (Hampton) | Woodland High School |
| 10/14/2022 | 7:30 PM | 3A | Wren High School | Palmetto High School | Wren High School |
| 10/20/2022 | 7:30 PM | 3A | North Charleston High School | Beaufort High School | Charleston D 4 Stadium |
| 10/21/2022 | 7:30 PM | 2A | Abbeville High School | Blacksburg High School | Abbeville High School |
| 10/21/2022 | 7:30 PM | 2A | Academic Magnet High School | Lake Marion High School & Technology Center | Ravenel Field |
| 10/21/2022 | 7:30 PM | 4A | Aiken High School | Lexington High School | Aiken High School |
| 10/21/2022 | 7:30 PM | 2A | Andrew Jackson High School | North Central High School | Andrew Jackson High School |
| 10/21/2022 | 7:30 PM | 1A | Bamberg-Ehrhardt High School | Allendale-fairfax High School | Bamberg-Ehrhardt High School |
| 10/21/2022 | 7:30 PM | 1A | Baptist Hill High School | Cross High School | Baptist Hill High School |
| 10/21/2022 | 7:30 PM | 2A | Barnwell High School | Woodland High School | Barnwell High School |
| 10/21/2022 | 7:30 PM | 2A | Batesburg-leesville High School | Pelion High School | Batesburg-Leesville High School |
| 10/21/2022 | 7:30 PM | 3A | Belton-honea Path High School | Southside High School | Belton-Honea Path High School |
| 10/21/2022 | 7:30 PM | 5A | Berkeley High School | Stratford High School | Berkeley High School |
| 10/21/2022 | 7:30 PM | 1A | Bowman High School | Estill High School | Bethune-Bowman Middle/High School |
| 10/21/2022 | 7:30 PM | 1A | Calhoun County High School | Ridge Spring-Monetta High School | Calhoun County High School |
| 10/21/2022 | 7:30 PM | 5A | Cane Bay High | R B Stall High School | Cane Bay High School |
| 10/21/2022 | 7:30 PM | 3A | Carolina High School | Gettys D Broome High School | Carolina High School |
| 10/21/2022 | 7:30 PM | 1A | Carvers Bay High School | East Clarendon High School | Carvers Bay High School |
| 10/21/2022 | 7:30 PM | 5A | Chapin High School | White Knoll High School | Chapin High School |
| 10/21/2022 | 7:30 PM | 3A | Chapman High School | Blue Ridge High School | Chapman High School |
| 10/21/2022 | 7:30 PM | 3A | Cheraw Senior High School | Buford High School | Cheraw Senior High School |
| 10/21/2022 | 7:30 PM | 2A | Chesnee High School | Ninety Six High School | Chesnee High School |
| 10/21/2022 | 7:30 PM | 3A | Chester High School | Clinton High School | Chester High School |
| 10/21/2022 | 7:30 PM | 2A | Chesterfield High School | Central High School | Chesterfield High School |
| 10/21/2022 | 7:30 PM | 3A | Crestwood High School | Camden High School | Sumter Dist. 2 – Sta |
| 10/21/2022 | 7:30 PM | 3A | D W Daniel High School | Pendleton High School | D W Daniel High School |
| 10/21/2022 | 7:30 PM | 3A | Darlington High School | Lakewood High School | Darlington High School |
| 10/21/2022 | 7:30 PM | 3A | Dreher High School | Gilbert High School | Memorial Stadium-Columbia |
| 10/21/2022 | 7:30 PM | 5A | Easley High School | Westside High School | Easley High School |
| 10/21/2022 | 7:30 PM | 2A | Edisto High School | Hardeeville | Edisto High School |
| 10/21/2022 | 7:30 PM | 3A | Emerald High School | Union High School | Emerald High School |
| 10/21/2022 | 7:30 PM | 3A | Fairfield Central High School | Eau Claire High School | Fairfield Central High School |
| 10/21/2022 | 7:30 PM | 5A | Fort Mill High School | Clover High School | Fort Mill High School |
| 10/21/2022 | 7:30 PM | 5A | Gaffney High School | Dorman High School | Gaffney High School |
| 10/21/2022 | 7:30 PM | 3A | Georgetown High School | Aynor High School | Georgetown High School |
| 10/21/2022 | 7:30 PM | 5A | Goose Creek High School | Wando High School | Goose Creek High School |
| 10/21/2022 | 7:30 PM | 1A | Great Falls High School | Mc Bee High School | Great Falls High School |
| 10/21/2022 | 7:30 PM | 1A | Green Sea Floyds High School | Hannah-pamplico High School | Green Sea Floyds High School |
| 10/21/2022 | 7:30 PM | 4A | Greenville Sr High School | Greenwood High School | G’ville’s – Sirrine Sta |
| 10/21/2022 | 7:30 PM | 5A | Greer Senior High School | Wade Hampton High School (Greenville) | Greer HS Stadium |
| 10/21/2022 | 7:30 PM | 3A | Hanahan High School | Philip Simmons High School | Hanahan High School |
| 10/21/2022 | 7:30 PM | 1A | Hemingway High School | Scott’s Branch | Hemingway High School |
| 10/21/2022 | 7:30 PM | 5A | Hillcrest High School | Mauldin High School | Hillcrest High School |
| 10/21/2022 | 7:30 PM | 4A | Hilton Head High School | James Island Charter High School | Hilton Head High School |
| 10/21/2022 | 7:30 PM | 4A | Indian Land High School | Catawba Ridge High School | Indian Land High School |
| 10/21/2022 | 7:30 PM | 5A | Irmo High School | Westwood High School | Irmo High School |
| 10/21/2022 | 7:30 PM | 2A | Kingstree Senior High School | Mullins High School | Kingstree Senior High School |
| 10/21/2022 | 7:30 PM | 1A | Lamar High School | Lake View High School | Lamar High School |
| 10/21/2022 | 7:30 PM | 4A | Lancaster High School | York Comprehensive High School | Lancaster High School |
| 10/21/2022 | 7:30 PM | 2A | Landrum High School | Liberty High School | Landrum High School |
| 10/21/2022 | 7:30 PM | 4A | Laurens District 55 High School | Eastside High School | Laurens District 55 High School |
| 10/21/2022 | 7:30 PM | 2A | Lee Central High | Andrews High School | Lee Central High School |
| 10/21/2022 | 7:30 PM | 3A | Lower Richland High School | Orangeburg-wilkinson High School | Lower Richland High School |
| 10/21/2022 | 7:30 PM | 4A | Lucy Beckham High School | Colleton County | Wando High School Stadium |
| 10/21/2022 | 7:30 PM | 4A | Lugoff-elgin High School | A C Flora High School | Lugoff-elgin Middle School |
| 10/21/2022 | 7:30 PM | 3A | Manning High School | Loris High School | Manning High School |
| 10/21/2022 | 7:30 PM | 3A | Marlboro County High School | Lake City High School | Marlboro County High School |
| 10/21/2022 | 7:30 PM | 4A | May River High School – Squad 1 | Bluffton High School | May River High School |
| 10/21/2022 | 7:30 PM | 1A | Mc Cormick High School | Calhoun Falls High School | McCormick High School |
| 10/21/2022 | 7:30 PM | 1A | Military Magnet Academy | St. John’s High School | Charleston District 4 Stadium |
| 10/21/2022 | 7:30 PM | 2A | Newberry High School | Columbia High School | Newberry High School |
| 10/21/2022 | 7:30 PM | 4A | North Augusta High School | Airport High School | North Augusta High School |
| 10/21/2022 | 7:30 PM | 4A | North Myrtle Beach High School | South Florence High School | North Myrtle Beach High School |
| 10/21/2022 | 7:30 PM | 2A | Oceanside Collegiate Academy | Bishop England High School | The Citadel |
| 10/21/2022 | 7:30 PM | 3A | Palmetto High School | Fountain Inn High School | Palmetto High School |
| 10/21/2022 | 7:30 PM | 4A | Pickens High School | Berea High School | Pickens High School |
| 10/21/2022 | 7:30 PM | 4A | Ridge View High School | Richland Northeast High School | Ridge View High School |
| 10/21/2022 | 7:30 PM | 5A | River Bluff High School | Dutch Fork High School | River Bluff High School |
| 10/21/2022 | 7:30 PM | 5A | Rock Hill High School | Blythewood High School | Rock Hill High School |
| 10/21/2022 | 7:30 PM | 2A | Saluda High School | Fox Creek High School | Saluda High School |
| 10/21/2022 | 7:30 PM | 2A | Silver Bluff High School | Strom Thurmond High School | Silver Bluff High School |
| 10/21/2022 | 7:30 PM | 5A | Socastee High School | Carolina Forest HS | Socastee High School |
| 10/21/2022 | 7:30 PM | 4A | South Aiken High School | Midland Valley High School | South Aiken High School |
| 10/21/2022 | 7:30 PM | 4A | South Pointe High School | Northwestern High School | South Pointe High School |
| 10/21/2022 | 7:30 PM | 1A | Southside Christian School | Ware Shoals High School | Southside Christian School |
| 10/21/2022 | 7:30 PM | 5A | Spartanburg High School | Boiling Springs High School | Spartanburg High School |
| 10/21/2022 | 7:30 PM | 5A | Spring Valley High School | Nation Ford High School | Spring Valley High School |
| 10/21/2022 | 7:30 PM | 5A | St. James High School | Sumter High School | St. James High School |
| 10/21/2022 | 7:30 PM | 2A | St. Joseph High School | Christ Church Episcopal School | St. Joseph High School |
| 10/21/2022 | 7:30 PM | 5A | Summerville High School | Ashley Ridge High | Summerville-Memorial Sta. |
| 10/21/2022 | 7:30 PM | 3A | Swansea High School | Brookland-Cayce High School | Swansea High School |
| 10/21/2022 | 7:30 PM | 3A | W J Keenan High School | Mid-carolina High School | Keenan High School |
| 10/21/2022 | 7:30 PM | 3A | Waccamaw High School | Dillon High School | Waccamaw High School |
| 10/21/2022 | 7:30 PM | 1A | Wagener-salley High School | Denmark-Olar High School | Wagener-Salley High School |
| 10/21/2022 | 7:30 PM | 3A | Walhalla Senior High School | Seneca | Walhalla High School |
| 10/21/2022 | 7:30 PM | 5A | West Ashley High School | Fort Dorchester High School | West Ashley High School |
| 10/21/2022 | 7:30 PM | 4A | West Florence High School | Hartsville High School | West Florence High School |
| 10/21/2022 | 7:30 PM | 3A | West Oak High School | Crescent High School | West Oak High School |
| 10/21/2022 | 7:30 PM | 1A | Whale Branch Early College High School | Branchville Middle High School | Whale Branch Early College High School |
| 10/21/2022 | 7:30 PM | 1A | Whitmire High School | Lewisville High School | Whitmire High School |
| 10/21/2022 | 7:30 PM | 1A | Williston-elko High School | Blackville-hilda High School | Williston-Elko High School |
| 10/21/2022 | 7:30 PM | 4A | Wilson High School | Myrtle Beach High School | Wilson High School |
| 10/21/2022 | 7:30 PM | 5A | Woodmont High School | T L Hanna High School | Woodmont High School |
| 10/21/2022 | 7:30 PM | 3A | Wren High School | Powdersville High School | Wren High School |
| 10/27/2022 | 5:30 PM | 5A | Mauldin High School | James Byrnes High School | Mauldin High School |
| 10/28/2022 | 7:30 PM | 4A | A C Flora High School | Ridge View High School | A C Flora High School |
| 10/28/2022 | 7:30 PM | 4A | Aiken High School | South Aiken High School | Aiken High School |
| 10/28/2022 | 7:30 PM | 1A | Allendale-fairfax High School | Estill High School | Allendale Fairfax High School |
| 10/28/2022 | 7:30 PM | 5A | Ashley Ridge High | R B Stall High School | Ashley Ridge High School |
| 10/28/2022 | 7:30 PM | 3A | Aynor High School | Loris High School | Aynor High School |
| 10/28/2022 | 7:30 PM | 1A | Bamberg-Ehrhardt High School | Whale Branch Early College High School | Bamberg-Ehrhardt High School |
| 10/28/2022 | 7:30 PM | 2A | Batesburg-leesville High School | Saluda High School | Batesburg-Leesville High School |
| 10/28/2022 | 7:30 PM | 3A | Beaufort High School | Hanahan High School | Beaufort High School |
| 10/28/2022 | 7:30 PM | 3A | Belton-honea Path High School | Wren High School | Belton-Honea Path High School |
| 10/28/2022 | 7:30 PM | 4A | Berea High School | Westside High School | Berea High School |
| 10/28/2022 | 7:30 PM | 2A | Bishop England High School | Academic Magnet High School | Bishop England High School |
| 10/28/2022 | 7:30 PM | 2A | Blacksburg High School | Landrum High School | Blacksburg High School |
| 10/28/2022 | 7:30 PM | 3A | Blue Ridge High School | Travelers Rest High School | Blue Ridge High School |
| 10/28/2022 | 7:30 PM | 4A | Bluffton High School | Colleton County | Bluffton High School |
| 10/28/2022 | 7:30 PM | 5A | Blythewood High School | Spring Valley High School | Blythewood High School |
| 10/28/2022 | 7:30 PM | 1A | Branchville Middle High School | Bowman High School | Branchville High School |
| 10/28/2022 | 7:30 PM | 2A | Buford High School | Andrew Jackson High School | Buford High School |
| 10/28/2022 | 7:30 PM | 2A | C A Johnson High School | Whitmire High School | Bolden Stadium |
| 10/28/2022 | 7:30 PM | 3A | Camden High School | Marlboro County High School | Camden City Arena |
| 10/28/2022 | 7:30 PM | 5A | Cane Bay High | Berkeley High School | Cane Bay High School |
| 10/28/2022 | 7:30 PM | 5A | Carolina Forest HS | St. James High School | Carolina Forest High School |
| 10/28/2022 | 7:30 PM | 2A | Central High School | North Central High School | Central High School |
| 10/28/2022 | 7:30 PM | 2A | Chesterfield High School | Cheraw Senior High School | Chesterfield High School |
| 10/28/2022 | 7:30 PM | 2A | Christ Church Episcopal School | Southside Christian School | Christ Church Episcopal School |
| 10/28/2022 | 7:30 PM | 3A | Clinton High School | Emerald High School | Clinton Middle School |
| 10/28/2022 | 7:30 PM | 5A | Clover High School | Rock Hill High School | Clover High School |
| 10/28/2022 | 7:30 PM | 3A | Crescent High School | D W Daniel High School | Crescent High School |
| 10/28/2022 | 7:30 PM | 1A | Cross High School | Burke High School | Cross High School |
| 10/28/2022 | 7:30 PM | 1A | Denmark-Olar High School | Williston-elko High School | Denmark-Olar High School |
| 10/28/2022 | 7:30 PM | 3A | Dillon High School | Georgetown High School | Dillon High School |
| 10/28/2022 | 7:30 PM | 1A | Dixie High School | Calhoun Falls High School | Dixie High School |
| 10/28/2022 | 7:30 PM | 5A | Dorman High School | Spartanburg High School | Dorman High School |
| 10/28/2022 | 7:30 PM | 5A | Easley High School | Greenville Sr High School | Easley High School |
| 10/28/2022 | 7:30 PM | 3A | Fairfield Central High School | Newberry High School | Fairfield Central High School |
| 10/28/2022 | 7:30 PM | 5A | Fort Dorchester High School | Summerville High School | Fort Dorchester High School |
| 10/28/2022 | 7:30 PM | 4A | Fountain Inn High School | Southside High School | Fountain Inn High School |
| 10/28/2022 | 7:30 PM | 3A | Gettys D Broome High School | Chapman High School | Gettys D. Broome High School |
| 10/28/2022 | 7:30 PM | 3A | Gilbert High School | Brookland-Cayce High School | Gilbert High School |
| 10/28/2022 | 7:30 PM | 2A | Gray Collegiate Academy | W J Keenan High School | Midland Dixie Youth Compex |
| 10/28/2022 | 7:30 PM | 1A | Hemingway High School | Johnsonville High School | Hemingway High School |
| 10/28/2022 | 7:30 PM | 5A | Irmo High School | Lugoff-elgin High School | Irmo High School |
| 10/28/2022 | 7:30 PM | 5A | J L Mann High School | Hillcrest High School | JL Mann High School |
| 10/28/2022 | 7:30 PM | 5A | James Byrnes High School | Gaffney High School | James F. Byrnes High School |
| 10/28/2022 | 7:30 PM | 5A | James Island Charter High School | Lucy Beckham High School | James Island Charter High School |
| 10/28/2022 | 7:30 PM | 2A | Kingstree Senior High School | Lee Central High | Kingstree Senior High School |
| 10/28/2022 | 7:30 PM | 3A | Lake City High School | Darlington High School | Lake City High School |
| 10/28/2022 | 7:30 PM | 2A | Lake Marion High School & Technology Center | Hardeeville | Lake Marion High School |
| 10/28/2022 | 7:30 PM | 1A | Lake View High School | Hannah-pamplico High School | Lake View High School |
| 10/28/2022 | 7:30 PM | 3A | Lakewood High School | Crestwood High School | Lakewood High School |
| 10/28/2022 | 7:30 PM | 4A | Lancaster High School | Indian Land High School | Lancaster High School |
| 10/28/2022 | 7:30 PM | 1A | Latta High School | Green Sea Floyds High School | Buddy Johnson Park – Latta |
| 10/28/2022 | 7:30 PM | 5A | Lexington High School | Dutch Fork High School | Lexington High School |
| 10/28/2022 | 7:30 PM | 2A | Liberty High School | Chesnee High School | Liberty HS |
| 10/28/2022 | 7:30 PM | 3A | Lower Richland High School | Dreher High School | Lower Richland High School |
| 10/28/2022 | 7:30 PM | 3A | Manning High School | Waccamaw High School | Manning High School |
| 10/28/2022 | 7:30 PM | 4A | May River High School – Squad 1 | Hilton Head High School | May River High School |
| 10/28/2022 | 7:30 PM | 1A | Mc Bee High School | Lewisville High School | Mc Bee High School |
| 10/28/2022 | 7:30 PM | 2A | Mid-carolina High School | Eau Claire High School | Mid Carolina High School |
| 10/28/2022 | 7:30 PM | 2A | Mullins High School | Marion High School | Mullins High School |
| 10/28/2022 | 7:30 PM | 5A | Nation Ford High School | Fort Mill High School | Nation Ford HS |
| 10/28/2022 | 7:30 PM | 2A | Ninety Six High School | Abbeville High School | Ninety Six High School |
| 10/28/2022 | 7:30 PM | 4A | North Augusta High School | Midland Valley High School | North Augusta High School |
| 10/28/2022 | 7:30 PM | 4A | North Myrtle Beach High School | Myrtle Beach High School | North Myrtle Beach High School |
| 10/28/2022 | 7:30 PM | 4A | Northwestern High School | Catawba Ridge High School | Northwestern High School |
| 10/28/2022 | 7:30 PM | 3A | Orangeburg-wilkinson High School | Swansea High School | Orangeburg-Wilkinson High School |
| 10/28/2022 | 7:30 PM | 2A | Pelion High School | Silver Bluff High School | Pelion High School |
| 10/28/2022 | 7:30 PM | 3A | Pendleton High School | Walhalla Senior High School | Pendleton High School |
| 10/28/2022 | 7:30 PM | 3A | Philip Simmons High School | Battery Creek High School | Philip Simmons High School |
| 10/28/2022 | 7:30 PM | 4A | Pickens High School | Greenwood High School | Pickens High School |
| 10/28/2022 | 7:30 PM | 3A | Powdersville High School | Palmetto High School | Powdersville High School |
| 10/28/2022 | 7:30 PM | 4A | Richland Northeast High School | Westwood High School | Richland Northeast High School |
| 10/28/2022 | 7:30 PM | 5A | River Bluff High School | Chapin High School | River Bluff High School |
| 10/28/2022 | 7:30 PM | 4A | Riverside High School | Greer Senior High School | Riverside High School |
| 10/28/2022 | 7:30 PM | 1A | Scott’s Branch | East Clarendon High School | Scott’s Branch HS |
| 10/28/2022 | 7:30 PM | 3A | Seneca | West Oak High School | Seneca High |
| 10/28/2022 | 7:30 PM | 4A | South Florence | West Florence High School | South Florence High School |
| 10/28/2022 | 7:30 PM | 1A | St. John’s High School | Baptist Hill High School | St. John’s High School |
| 10/28/2022 | 7:30 PM | 2A | St. Joseph High School | Mc Cormick High School | St. Joseph High School |
| 10/28/2022 | 7:30 PM | 5A | Stratford High School | Goose Creek High School | Stratford High School |
| 10/28/2022 | 7:30 PM | 2A | Strom Thurmond High School | Fox Creek High School | Strom Thurmond H |
| 10/28/2022 | 7:30 PM | 5A | Sumter High School | Conway High School | Sumter-Memorial Sta |
| 10/28/2022 | 7:30 PM | 2A | Timberland High School | Oceanside Collegiate Academy | Timberland High School |
| 10/28/2022 | 7:30 PM | 4A | Wade Hampton High School (Greenville) | Eastside High School | Wade Hampton High School (G) |
| 10/28/2022 | 7:30 PM | 2A | Wade Hampton High School (Hampton) | Barnwell High School | Wade Hampton High School (H) |
| 10/28/2022 | 7:30 PM | 1A | Wagener-salley High School | Calhoun County High School | Wagener-Salley High School |
| 10/28/2022 | 7:30 PM | 5A | Wando High School | Socastee High School | Wando High School Stadium |
| 10/28/2022 | 7:30 PM | 4A | Wilson High School | Hartsville High School | Wilson High School |
| 10/28/2022 | 7:30 PM | 2A | Woodland High School | Edisto High School | Woodland High School |
| 10/28/2022 | 7:30 PM | 5A | Woodmont High School | Mauldin High School | Woodmont High School |
| 10/28/2022 | 7:30 PM | 3A | Woodruff High School | Union High School | Woodruff High School |
| 10/28/2022 | 7:30 PM | 4A | York Comprehensive High School | South Pointe High School | York High School |
| 10/28/2022 | 8:00 PM | 1A | Hunter-kinard-tyler Middle High School | Ridge Spring-Monetta High School | Hunter-Kinard-Tyler High School |
